Detailed information of TA system TA239709

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hokW-rdlD/-
• Location: 2102872..2103097
• Replicon: chromosome
• Accession: NZ_CP094339
• Organism: Escherichia coli strain W224N

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: MQV61_RS09960
• Protein ID: WP_000813254.1
• Coordinates: 2102942..2103097 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2102872..2102930 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQV61_RS09915	2098134..2098286	-	153	WP_000379609.1	DUF1391 family protein	-
MQV61_RS09920	2098558..2098845	-	288	WP_000936799.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MQV61_RS09925	2098845..2099036	-	192	WP_000100899.1	hypothetical protein	-
MQV61_RS09930	2099064..2099465	-	402	WP_001329851.1	helix-turn-helix domain-containing protein	-
MQV61_RS09935	2099575..2099847	+	273	WP_000887447.1	YdaS family helix-turn-helix protein	-
MQV61_RS09940	2099831..2100256	+	426	WP_000693918.1	toxin YdaT family protein	-
MQV61_RS09945	2100328..2101398	+	1071	WP_001262355.1	hypothetical protein	-
MQV61_RS09950	2101439..2101864	+	426	WP_001151152.1	DUF977 family protein	-
MQV61_RS09955	2102039..2102704	+	666	WP_000150294.1	epoxyqueuosine reductase QueH	-
-	2102872..2102930	-	59	-	-	Antitoxin
MQV61_RS09960	2102942..2103097	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
MQV61_RS09965	2103265..2103543	+	279	WP_024193993.1	hypothetical protein	-
MQV61_RS09970	2103545..2104594	+	1050	WP_001265292.1	DUF968 domain-containing protein	-
MQV61_RS09975	2104607..2104981	+	375	WP_001217427.1	RusA family crossover junction endodeoxyribonuclease	-
MQV61_RS09980	2104978..2105799	+	822	WP_001235237.1	antitermination protein	-
MQV61_RS09985	2106045..2106758	+	714	WP_000342820.1	hypothetical protein	-
MQV61_RS10010	2107483..2107698	+	216	WP_000839572.1	class II holin family protein	-
MQV61_RS10015	2107703..2107786	+	84	Protein_1959	DUF1327 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2088614..2107698	19084

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T239709 WP_000813254.1 NZ_CP094339:2102942-2103097 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T239709 NZ_LS483308:c2088048-2087686 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT239709 NZ_CP094339:c2102930-2102872 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin