Detailed information of TA system TA239700

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 52507..52933
• Replicon: plasmid pST3606-2
• Accession: NZ_CP094334
• Organism: Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MQF88_RS25385
• Protein ID: WP_001372321.1
• Coordinates: 52507..52632 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	52709..52933 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQF88_RS25350 (47579)	47579..47749	-	171	WP_242935023.1	TraY domain-containing protein	-
MQF88_RS25355 (47886)	47886..48569	-	684	Protein_59	PAS domain-containing protein	-
MQF88_RS25360 (48760)	48760..49143	-	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MQF88_RS25365 (49420)	49420..50067	+	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
MQF88_RS25370 (50364)	50364..51185	-	822	WP_001234445.1	DUF932 domain-containing protein	-
MQF88_RS25375 (51296)	51296..51592	-	297	WP_001272251.1	hypothetical protein	-
MQF88_RS25380 (51892)	51892..52188	+	297	Protein_64	hypothetical protein	-
MQF88_RS25385 (52507)	52507..52632	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
MQF88_RS25390 (52574)	52574..52723	-	150	Protein_66	plasmid maintenance protein Mok	-
- (52709)	52709..52933	-	225	NuclAT_0	-	Antitoxin
- (52709)	52709..52933	-	225	NuclAT_0	-	Antitoxin
- (52709)	52709..52933	-	225	NuclAT_0	-	Antitoxin
- (52709)	52709..52933	-	225	NuclAT_0	-	Antitoxin
MQF88_RS25395 (52945)	52945..53664	-	720	WP_001276217.1	plasmid SOS inhibition protein A	-
MQF88_RS25400 (53661)	53661..54095	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
MQF88_RS25405 (54164)	54164..56187	-	2024	Protein_69	ParB/RepB/Spo0J family partition protein	-
MQF88_RS25410 (56248)	56248..56481	-	234	WP_000006003.1	DUF905 family protein	-
MQF88_RS25415 (56539)	56539..57066	-	528	WP_000290834.1	single-stranded DNA-binding protein	-
MQF88_RS25420 (57368)	57368..57823	+	456	Protein_72	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaTEM-1B / aac(3)-IId	-	1..70455	70455

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T239700 WP_001372321.1 NZ_CP094334:c52632-52507 [Salmonella enterica subsp. enterica]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T239700 NZ_LS483305:118266-118532 [Mammaliicoccus sciuri]
ATGAGTAAACGAAACATTACATTTACGCCTACCGCTTTTGAAGATTATGAGTATTGGCTAGCACAAGATAAAAAGTTATT
AAAGAAGATTAACAGTCTAATAAAAAGTATTCAGCGCGATGGCCAATTAGAAGGAGAAGGTAAACCTGAACCACTAAAAG
GCAATTTACAAGGCTACTGTAGTAGACGTATTAATCATGAACACAGACTAGTTTATATGGTTAAAGAAAATCACATTATC
ATTATAGGATGTAGATATCATTATTAA

Antitoxin

Nucleotide

• Length: 225 bp

>AT239700 NZ_CP094334:c52933-52709 [Salmonella enterica subsp. enterica]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin