Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4764509..4765263 | Replicon | chromosome |
Accession | NZ_CP094332 | ||
Organism | Salmonella enterica subsp. enterica strain 3018683606 |
Toxin (Protein)
Gene name | higB | Uniprot ID | B5F003 |
Locus tag | MQF88_RS23485 | Protein ID | WP_000558166.1 |
Coordinates | 4764509..4764820 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | MQF88_RS23490 | Protein ID | WP_001259011.1 |
Coordinates | 4764817..4765263 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MQF88_RS23455 (4760167) | 4760167..4761069 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
MQF88_RS23460 (4761066) | 4761066..4761701 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
MQF88_RS23465 (4761698) | 4761698..4762627 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
MQF88_RS23470 (4762674) | 4762674..4762964 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
MQF88_RS23475 (4762965) | 4762965..4763276 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
MQF88_RS23480 (4763494) | 4763494..4764423 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
MQF88_RS23485 (4764509) | 4764509..4764820 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
MQF88_RS23490 (4764817) | 4764817..4765263 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
MQF88_RS23495 (4765278) | 4765278..4766219 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
MQF88_RS23500 (4766264) | 4766264..4766701 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
MQF88_RS23505 (4766698) | 4766698..4767570 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
MQF88_RS23510 (4767564) | 4767564..4768163 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
MQF88_RS23515 (4768354) | 4768354..4769157 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
MQF88_RS23520 (4769191) | 4769191..4770087 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T239691 WP_000558166.1 NZ_CP094332:4764509-4764820 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T239691 NZ_LS483303:2592964-2593071 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT239691 WP_001259011.1 NZ_CP094332:4764817-4765263 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT239691 NZ_LS483303:c2592917-2592851 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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