Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4764509..4765263 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag MQF88_RS23485 Protein ID WP_000558166.1
Coordinates 4764509..4764820 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MQF88_RS23490 Protein ID WP_001259011.1
Coordinates 4764817..4765263 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS23455 (4760167) 4760167..4761069 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
MQF88_RS23460 (4761066) 4761066..4761701 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
MQF88_RS23465 (4761698) 4761698..4762627 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
MQF88_RS23470 (4762674) 4762674..4762964 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
MQF88_RS23475 (4762965) 4762965..4763276 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
MQF88_RS23480 (4763494) 4763494..4764423 + 930 WP_001127703.1 alpha/beta hydrolase -
MQF88_RS23485 (4764509) 4764509..4764820 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
MQF88_RS23490 (4764817) 4764817..4765263 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
MQF88_RS23495 (4765278) 4765278..4766219 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
MQF88_RS23500 (4766264) 4766264..4766701 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
MQF88_RS23505 (4766698) 4766698..4767570 - 873 WP_000921427.1 virulence factor BrkB family protein -
MQF88_RS23510 (4767564) 4767564..4768163 - 600 WP_000965695.1 glucose-1-phosphatase -
MQF88_RS23515 (4768354) 4768354..4769157 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
MQF88_RS23520 (4769191) 4769191..4770087 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T239691 WP_000558166.1 NZ_CP094332:4764509-4764820 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T239691 NZ_LS483303:2592964-2593071 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT239691 WP_001259011.1 NZ_CP094332:4764817-4765263 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT239691 NZ_LS483303:c2592917-2592851 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References