239682

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2401668..2402190 Replicon chromosome
Accession NZ_CP094332
Organism Salmonella enterica subsp. enterica strain 3018683606

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MQF88_RS11885 Protein ID WP_000221343.1
Coordinates 2401906..2402190 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MQF88_RS11880 Protein ID WP_000885424.1
Coordinates 2401668..2401916 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQF88_RS11855 (2396884) 2396884..2398350 + 1467 WP_000987828.1 hypothetical protein -
MQF88_RS11860 (2399158) 2399158..2399872 + 715 Protein_2322 helix-turn-helix domain-containing protein -
MQF88_RS11865 (2399928) 2399928..2400836 - 909 WP_010989018.1 hypothetical protein -
MQF88_RS11870 (2400979) 2400979..2401311 - 333 WP_000253154.1 DUF1493 family protein -
MQF88_RS11875 (2401301) 2401301..2401516 - 216 WP_000206207.1 hypothetical protein -
MQF88_RS11880 (2401668) 2401668..2401916 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MQF88_RS11885 (2401906) 2401906..2402190 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQF88_RS11890 (2402361) 2402361..2402750 + 390 WP_000194089.1 RidA family protein -
MQF88_RS11895 (2402802) 2402802..2403881 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MQF88_RS11900 (2404074) 2404074..2404562 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
MQF88_RS11905 (2404607) 2404607..2406115 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2396887..2408972 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T239682 WP_000221343.1 NZ_CP094332:2401906-2402190 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T239682 NZ_LS483302:c2099232-2099023 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT239682 WP_000885424.1 NZ_CP094332:2401668-2401916 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT239682 NZ_LS483302:c2099537-2099244 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References