Detailed information of TA system TA239467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 10533..11191
• Replicon: plasmid pNY5301-2
• Accession: NZ_CP094285
• Organism: Acinetobacter baumannii strain NY5301

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MQE20_RS20400
• Protein ID: WP_000312250.1
• Coordinates: 10832..11191 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MQE20_RS20395
• Protein ID: WP_001096429.1
• Coordinates: 10533..10832 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE20_RS20360 (MQE20_20360)	6591..6848	+	258	WP_166686224.1	hypothetical protein	-
MQE20_RS20365 (MQE20_20365)	6853..7425	+	573	WP_000443897.1	hypothetical protein	-
MQE20_RS20370 (MQE20_20370)	7401..7580	+	180	WP_033854395.1	hypothetical protein	-
MQE20_RS20375 (MQE20_20375)	7597..8226	+	630	WP_166686223.1	hypothetical protein	-
MQE20_RS20380 (MQE20_20380)	8266..8775	+	510	WP_166686222.1	hypothetical protein	-
MQE20_RS20385 (MQE20_20385)	8856..9410	+	555	WP_038337781.1	hypothetical protein	-
MQE20_RS20390 (MQE20_20390)	9460..9996	+	537	WP_038337775.1	hypothetical protein	-
MQE20_RS20395 (MQE20_20395)	10533..10832	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
MQE20_RS20400 (MQE20_20400)	10832..11191	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQE20_RS20405 (MQE20_20405)	11392..11958	+	567	WP_000710385.1	hypothetical protein	-
MQE20_RS20410 (MQE20_20410)	12007..12189	+	183	WP_000373385.1	hypothetical protein	-
MQE20_RS20415 (MQE20_20415)	12256..12954	+	699	WP_033854396.1	hypothetical protein	-
MQE20_RS20420 (MQE20_20420)	13093..13476	+	384	WP_000654348.1	hypothetical protein	-
MQE20_RS20425 (MQE20_20425)	13543..14301	+	759	WP_033854397.1	hypothetical protein	-
MQE20_RS20430 (MQE20_20430)	14353..14688	+	336	WP_166686221.1	hypothetical protein	-
MQE20_RS20435 (MQE20_20435)	15555..15869	+	315	WP_000708713.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..71194	71194

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T239467 WP_000312250.1 NZ_CP094285:c11191-10832 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T239467 NZ_LR890724:c63778-63398 [Klebsiella pneumoniae]
ATGAGACATATATCACCGGAAGAACTTGTTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT239467 WP_001096429.1 NZ_CP094285:c10832-10533 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT239467 NZ_LR890724:c63999-63778 [Klebsiella pneumoniae]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA