Detailed information of TA system TA239439

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 65053..65322
• Replicon: plasmid pNY1688-1
• Accession: NZ_CP094273
• Organism: Klebsiella aerogenes strain NY1688

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MQE04_RS26315
• Protein ID: WP_001372321.1
• Coordinates: 65197..65322 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	65053..65118 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE04_RS26285	60763..61290	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
MQE04_RS26290	61348..61581	+	234	WP_000006003.1	DUF905 family protein	-
MQE04_RS26295	61642..63665	+	2024	Protein_84	ParB/RepB/Spo0J family partition protein	-
MQE04_RS26300	63734..64168	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
MQE04_RS26305	64165..64884	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	64896..65120	+	225	NuclAT_0	-	-
-	64896..65120	+	225	NuclAT_0	-	-
-	64896..65120	+	225	NuclAT_0	-	-
-	64896..65120	+	225	NuclAT_0	-	-
-	65053..65118	-	66	-	-	Antitoxin
MQE04_RS26310	65106..65255	+	150	Protein_87	plasmid maintenance protein Mok	-
MQE04_RS26315	65197..65322	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
MQE04_RS26320	65641..65937	-	297	Protein_89	hypothetical protein	-
MQE04_RS26325	66237..66533	+	297	WP_001272251.1	hypothetical protein	-
MQE04_RS26330	66644..67465	+	822	WP_001234445.1	DUF932 domain-containing protein	-
MQE04_RS26335	67762..68352	-	591	WP_000252683.1	transglycosylase SLT domain-containing protein	-
MQE04_RS26340	68687..69070	+	384	WP_001354030.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MQE04_RS26345	69264..69935	+	672	WP_000283561.1	conjugal transfer transcriptional regulator TraJ	-
MQE04_RS26350	70072..70299	+	228	WP_000089263.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaTEM-1B / dfrA25 / qacE / sul1 / mph(A) / blaKPC-2	-	1..106628	106628

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T239439 WP_001372321.1 NZ_CP094273:65197-65322 [Klebsiella aerogenes]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T239439 NZ_LR890714:c4730844-4730671 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT239439 NZ_CP094273:c65118-65053 [Klebsiella aerogenes]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin