Detailed information of TA system TA239400

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2480503..2480728
• Replicon: chromosome
• Accession: NZ_CP094269
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain JL228

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: MPK88_RS12180
• Protein ID: WP_000813254.1
• Coordinates: 2480503..2480658 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2480670..2480728 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPK88_RS12145	2475610..2475891	-	282	WP_000445513.1	phage holin family protein	-
MPK88_RS12150	2475881..2476069	-	189	WP_001688615.1	putative holin	-
MPK88_RS12155	2476063..2476386	-	324	Protein_2379	tellurite/colicin resistance protein	-
MPK88_RS12160	2478557..2479093	-	537	WP_000640113.1	DUF1133 family protein	-
MPK88_RS12165	2479090..2479380	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
MPK88_RS12170	2479380..2479979	-	600	WP_000940751.1	DUF1367 family protein	-
MPK88_RS12175	2480042..2480212	-	171	WP_000734094.1	hypothetical protein	-
MPK88_RS12180	2480503..2480658	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2480670..2480728	+	59	-	-	Antitoxin
MPK88_RS12185	2481085..2481324	+	240	WP_000556391.1	hypothetical protein	-
MPK88_RS12190	2481612..2482016	+	405	WP_065314251.1	hypothetical protein	-
MPK88_RS12195	2482013..2482567	+	555	WP_001033796.1	hypothetical protein	-
MPK88_RS12200	2482729..2483058	-	330	WP_001676916.1	DUF977 family protein	-
MPK88_RS12205	2483102..2483149	-	48	Protein_2389	hypothetical protein	-
MPK88_RS12210	2483331..2483798	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
MPK88_RS12215	2484183..2484338	+	156	WP_085981757.1	DUF1391 family protein	-
MPK88_RS12220	2484446..2484967	-	522	WP_000004762.1	super-infection exclusion protein B	-
MPK88_RS12225	2485405..2485626	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2475068..2484967	9899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T239400 WP_000813254.1 NZ_CP094269:c2480658-2480503 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T239400 NZ_LR890706:28345-28503 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT239400 NZ_CP094269:2480670-2480728 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin