239393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1923396..1923913 Replicon chromosome
Accession NZ_CP094264
Organism Streptomyces sp. MRC013

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LUW75_RS08535 Protein ID WP_250335082.1
Coordinates 1923396..1923656 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LUW75_RS08540 Protein ID WP_250335083.1
Coordinates 1923653..1923913 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUW75_RS08510 (LUW75_08510) 1918494..1918853 + 360 WP_250335077.1 pentapeptide repeat-containing protein -
LUW75_RS08515 (LUW75_08515) 1918904..1919512 - 609 WP_250335078.1 SMI1/KNR4 family protein -
LUW75_RS08520 (LUW75_08520) 1919544..1921070 - 1527 WP_250335079.1 NAD(P)H-hydrate dehydratase -
LUW75_RS08525 (LUW75_08525) 1921075..1921443 - 369 WP_250335080.1 holo-ACP synthase -
LUW75_RS08530 (LUW75_08530) 1921440..1923287 - 1848 WP_250335081.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
LUW75_RS08535 (LUW75_08535) 1923396..1923656 - 261 WP_250335082.1 Txe/YoeB family addiction module toxin Toxin
LUW75_RS08540 (LUW75_08540) 1923653..1923913 - 261 WP_250335083.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LUW75_RS08545 (LUW75_08545) 1924102..1925067 + 966 WP_250337600.1 type I pantothenate kinase -
LUW75_RS08550 (LUW75_08550) 1925179..1926537 - 1359 WP_250335084.1 phosphoglucosamine mutase -
LUW75_RS08555 (LUW75_08555) 1926645..1927163 - 519 WP_250335085.1 30S ribosomal protein S9 -
LUW75_RS08560 (LUW75_08560) 1927204..1927647 - 444 WP_010476323.1 50S ribosomal protein L13 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10122.55 Da        Isoelectric Point: 10.2237

>T239393 WP_250335082.1 NZ_CP094264:c1923656-1923396 [Streptomyces sp. MRC013]
VKKLFSSTAWEQYAHWATADPKILKKTNRLIKDIERTPFEGMGKPEPLKGNLSGWWSRRITDEHRLVYRAHDDRVEIALA
RYHYGA

Download         Length: 261 bp

>T239393 NZ_LR890702:3705334-3705717 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9445.43 Da        Isoelectric Point: 4.1725

>AT239393 WP_250335083.1 NZ_CP094264:c1923913-1923653 [Streptomyces sp. MRC013]
MSISASKARDELFPLIEKVNNDHEPVHITSRKGNAYLIAEDDFRGWQETAYLLRSPANARVLMDSIAELDAGEGQIGDLV
DTGGDE

Download         Length: 261 bp

>AT239393 NZ_LR890702:3705092-3705334 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References