Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 10083..10668 Replicon plasmid pBDT201-1
Accession NZ_CP094259
Organism Acinetobacter indicus strain BDT201

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MOW14_RS14330 Protein ID WP_016807108.1
Coordinates 10348..10668 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MOW14_RS14325 Protein ID WP_004641921.1
Coordinates 10083..10355 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOW14_RS14300 (MOW14_14300) 5527..5916 - 390 WP_032040164.1 tautomerase family protein -
MOW14_RS14305 (MOW14_14305) 6106..7431 + 1326 WP_242898203.1 ISNCY family transposase -
MOW14_RS14310 (MOW14_14310) 7579..8211 - 633 WP_104988442.1 hypothetical protein -
MOW14_RS14315 (MOW14_14315) 8208..9062 - 855 WP_104988441.1 PAAR domain-containing protein -
MOW14_RS14320 (MOW14_14320) 9055..9504 - 450 WP_104988440.1 PAAR domain-containing protein -
MOW14_RS14325 (MOW14_14325) 10083..10355 - 273 WP_004641921.1 NadS family protein Antitoxin
MOW14_RS14330 (MOW14_14330) 10348..10668 - 321 WP_016807108.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOW14_RS14335 (MOW14_14335) 10817..11443 + 627 WP_242898270.1 hypothetical protein -
MOW14_RS14340 (MOW14_14340) 11490..11783 + 294 WP_104472899.1 hypothetical protein -
MOW14_RS14345 (MOW14_14345) 11787..12185 + 399 WP_242898271.1 protein-export chaperone SecB -
MOW14_RS14350 (MOW14_14350) 12215..13018 - 804 WP_104472897.1 abortive infection family protein -
MOW14_RS14355 (MOW14_14355) 13101..13271 - 171 WP_002067611.1 hypothetical protein -
MOW14_RS14360 (MOW14_14360) 13274..13645 - 372 WP_005174618.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 6094..7431 1337
- inside Non-Mobilizable plasmid - - 1..14897 14897


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12237.02 Da        Isoelectric Point: 7.9849

>T239392 WP_016807108.1 NZ_CP094259:c10668-10348 [Acinetobacter indicus]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T239392 NZ_LR890702:c3291852-3291484 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10108.56 Da        Isoelectric Point: 7.2045

>AT239392 WP_004641921.1 NZ_CP094259:c10355-10083 [Acinetobacter indicus]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT239392 NZ_LR890702:c3292070-3291849 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References