Detailed information of TA system TA239345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 347637..348313
• Replicon: chromosome
• Accession: NZ_CP094237
• Organism: Klebsiella pneumoniae strain K41

Toxin (Protein)

• Gene name: higB
• Uniprot ID: W9BBY1
• Locus tag: MQE26_RS01605
• Protein ID: WP_016529833.1
• Coordinates: 347637..347984 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MQE26_RS01610
• Protein ID: WP_032413101.1
• Coordinates: 347984..348313 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE26_RS01595 (MQE26_01595)	343563..344996	+	1434	WP_002920564.1	glycogen synthase GlgA	-
MQE26_RS01600 (MQE26_01600)	345014..347461	+	2448	WP_102001163.1	glycogen phosphorylase	-
MQE26_RS01605 (MQE26_01605)	347637..347984	+	348	WP_016529833.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQE26_RS01610 (MQE26_01610)	347984..348313	+	330	WP_032413101.1	XRE family transcriptional regulator	Antitoxin
MQE26_RS01615 (MQE26_01615)	348346..349854	-	1509	WP_002920554.1	glycerol-3-phosphate dehydrogenase	-
MQE26_RS01620 (MQE26_01620)	350059..350388	+	330	WP_002920552.1	thiosulfate sulfurtransferase GlpE	-
MQE26_RS01625 (MQE26_01625)	350439..351269	+	831	WP_004151408.1	rhomboid family intramembrane serine protease GlpG	-
MQE26_RS01630 (MQE26_01630)	351319..352077	+	759	WP_002920548.1	DeoR/GlpR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-87)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13549.56 Da
• Isoelectric Point: 5.6749

>T239345 WP_016529833.1 NZ_CP094237:347637-347984 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Nucleotide

• Length: 348 bp

>T239345 NZ_LR890687:25182-25652 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAAACGTTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCACAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACACATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11921.98 Da
• Isoelectric Point: 10.8046

>AT239345 WP_032413101.1 NZ_CP094237:347984-348313 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNLLTGIRAKRKP

Nucleotide

• Length: 330 bp

>AT239345 NZ_LR890687:24742-25185 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTGCTGGGTCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AAAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGACTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: W9BBY1