Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1440531..1441119 Replicon chromosome
Accession NZ_CP094151
Organism Helicobacter pylori strain Hpfe019

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPG81_RS06860 Protein ID WP_180676138.1
Coordinates 1440838..1441119 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPG81_RS06855 Protein ID WP_154460569.1
Coordinates 1440531..1440845 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG81_RS06835 (MPG81_06835) 1436085..1436737 + 653 Protein_1330 ParA family protein -
MPG81_RS06840 (MPG81_06840) 1436822..1437106 + 285 WP_000394639.1 hypothetical protein -
MPG81_RS06845 (MPG81_06845) 1437138..1438301 + 1164 WP_245086871.1 hypothetical protein -
MPG81_RS06850 (MPG81_06850) 1438325..1440235 - 1911 WP_245086873.1 relaxase/mobilization nuclease domain-containing protein -
MPG81_RS06855 (MPG81_06855) 1440531..1440845 + 315 WP_154460569.1 hypothetical protein Antitoxin
MPG81_RS06860 (MPG81_06860) 1440838..1441119 + 282 WP_180676138.1 YafQ family addiction module toxin Toxin
MPG81_RS06865 (MPG81_06865) 1441164..1442000 - 837 Protein_1336 hypothetical protein -
MPG81_RS06870 (MPG81_06870) 1442011..1442775 - 765 WP_245086875.1 hypothetical protein -
MPG81_RS06875 (MPG81_06875) 1442833..1443927 - 1095 Protein_1338 5-methyltetrahydrofolate--homocysteine methyltransferase -
MPG81_RS06880 (MPG81_06880) 1443937..1444197 - 261 WP_000049130.1 WXG100 family type VII secretion target -
MPG81_RS06885 (MPG81_06885) 1444213..1444782 - 570 WP_245086877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10865.82 Da        Isoelectric Point: 9.2380

>T239288 WP_180676138.1 NZ_CP094151:1440838-1441119 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGCIKESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T239288 NZ_LR890665:789531-789941 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12135.56 Da        Isoelectric Point: 5.2066

>AT239288 WP_154460569.1 NZ_CP094151:1440531-1440845 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAVKKIQECELQEQMIRQVLAQKHSQEREPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239288 NZ_LR890665:789284-789550 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References