Detailed information of TA system TA239279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 483924..484512
• Replicon: chromosome
• Accession: NZ_CP094144
• Organism: Helicobacter pylori strain Hpfe029

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: -
• Locus tag: MPG75_RS02400
• Protein ID: WP_245039765.1
• Coordinates: 484231..484512 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPG75_RS02395
• Protein ID: WP_245039763.1
• Coordinates: 483924..484238 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG75_RS02375 (MPG75_02375)	479485..480141	+	657	WP_245039759.1	ParA family protein	-
MPG75_RS02380 (MPG75_02380)	480226..480510	+	285	WP_000394639.1	hypothetical protein	-
MPG75_RS02385 (MPG75_02385)	480542..481705	+	1164	WP_245039761.1	hypothetical protein	-
MPG75_RS02390 (MPG75_02390)	481729..483639	-	1911	Protein_457	relaxase/mobilization nuclease domain-containing protein	-
MPG75_RS02395 (MPG75_02395)	483924..484238	+	315	WP_245039763.1	hypothetical protein	Antitoxin
MPG75_RS02400 (MPG75_02400)	484231..484512	+	282	WP_245039765.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MPG75_RS02405 (MPG75_02405)	484781..486508	-	1728	WP_245039767.1	type IV secretory system conjugative DNA transfer family protein	-
MPG75_RS02410 (MPG75_02410)	486509..486889	-	381	Protein_461	HNH endonuclease family protein	-
MPG75_RS02415 (MPG75_02415)	486942..487085	-	144	Protein_462	DUF262 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	459247..500165	40918

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10867.84 Da
• Isoelectric Point: 9.6337

>T239279 WP_245039765.1 NZ_CP094144:484231-484512 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDVTSVVDCLKEQKPLQQKHCDHALSGNLKGLMECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239279 NZ_LR890657:c4131053-4130664 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAAGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAGAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12149.63 Da
• Isoelectric Point: 5.2066

>AT239279 WP_245039763.1 NZ_CP094144:483924-484238 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKVIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239279 NZ_LR890657:c4131320-4131057 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG