Detailed information of TA system TA239276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 525534..526122
• Replicon: chromosome
• Accession: NZ_CP094143
• Organism: Helicobacter pylori strain Hpfe032

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: -
• Locus tag: MPG16_RS02545
• Protein ID: WP_245108763.1
• Coordinates: 525534..525815 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: T5CU17
• Locus tag: MPG16_RS02550
• Protein ID: WP_000065285.1
• Coordinates: 525808..526122 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG16_RS02510 (MPG16_02510)	520746..520949	+	204	WP_245108921.1	hypothetical protein	-
MPG16_RS02515 (MPG16_02515)	520946..521244	+	299	Protein_482	hypothetical protein	-
MPG16_RS02520 (MPG16_02520)	521244..522184	+	941	Protein_483	ATPase, T2SS/T4P/T4SS family	-
MPG16_RS02525 (MPG16_02525)	522181..522635	+	455	Protein_484	mobilization protein	-
MPG16_RS02530 (MPG16_02530)	522632..522922	+	291	WP_245108761.1	hypothetical protein	-
MPG16_RS02535 (MPG16_02535)	522923..523480	+	558	Protein_486	hypothetical protein	-
MPG16_RS02540 (MPG16_02540)	523481..525208	+	1728	WP_245108762.1	type IV secretory system conjugative DNA transfer family protein	-
MPG16_RS02545 (MPG16_02545)	525534..525815	-	282	WP_245108763.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
MPG16_RS02550 (MPG16_02550)	525808..526122	-	315	WP_000065285.1	hypothetical protein	Antitoxin
MPG16_RS02555 (MPG16_02555)	526417..528327	+	1911	WP_245108764.1	relaxase/mobilization nuclease domain-containing protein	-
MPG16_RS02560 (MPG16_02560)	528352..529515	-	1164	WP_245108765.1	hypothetical protein	-
MPG16_RS02565 (MPG16_02565)	529547..529816	-	270	WP_245108766.1	hypothetical protein	-
MPG16_RS02570 (MPG16_02570)	529891..530547	-	657	WP_140565773.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10998.94 Da
• Isoelectric Point: 9.8376

>T239276 WP_245108763.1 NZ_CP094143:c525815-525534 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVVSIVDRLKEQKPLQQKYCDHALGGNLKELRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239276 NZ_LR890657:1846285-1846539 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12089.52 Da
• Isoelectric Point: 5.2066

>AT239276 WP_000065285.1 NZ_CP094143:c526122-525808 [Helicobacter pylori]
VSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239276 NZ_LR890657:1846539-1846880 [Serratia marcescens]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGCGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTTAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Structures

Antitoxin

• AlphaFold DB: T5CU17