Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1569214..1569802 Replicon chromosome
Accession NZ_CP094138
Organism Helicobacter pylori strain Hpfe037

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPG35_RS07560 Protein ID WP_180653715.1
Coordinates 1569214..1569495 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPG35_RS07565 Protein ID WP_245019597.1
Coordinates 1569488..1569802 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG35_RS07545 (MPG35_07545) 1564886..1566790 - 1905 Protein_1469 HsdR family type I site-specific deoxyribonuclease -
MPG35_RS07550 (MPG35_07550) 1566775..1567214 + 440 Protein_1470 hypothetical protein -
MPG35_RS07555 (MPG35_07555) 1567215..1568942 + 1728 WP_245019596.1 type IV secretory system conjugative DNA transfer family protein -
MPG35_RS07560 (MPG35_07560) 1569214..1569495 - 282 WP_180653715.1 YafQ family addiction module toxin Toxin
MPG35_RS07565 (MPG35_07565) 1569488..1569802 - 315 WP_245019597.1 hypothetical protein Antitoxin
MPG35_RS07570 (MPG35_07570) 1570087..1571997 + 1911 Protein_1474 relaxase/mobilization nuclease domain-containing protein -
MPG35_RS07575 (MPG35_07575) 1572021..1573154 - 1134 WP_245020027.1 hypothetical protein -
MPG35_RS07580 (MPG35_07580) 1573238..1573522 - 285 WP_000394639.1 hypothetical protein -
MPG35_RS07585 (MPG35_07585) 1573604..1573747 - 144 Protein_1477 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10905.83 Da        Isoelectric Point: 9.5726

>T239268 WP_180653715.1 NZ_CP094138:c1569495-1569214 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELI
LLRLDTHSELFKK

Download         Length: 282 bp

>T239268 NZ_LR890652:181889-182287 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGTTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12219.77 Da        Isoelectric Point: 6.7134

>AT239268 WP_245019597.1 NZ_CP094138:c1569802-1569488 [Helicobacter pylori]
MSNIITDYSQYNKKQLHNFLNAIEKQLLKAERDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239268 NZ_LR890652:181662-181889 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References