239261

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1262794..1263382 Replicon chromosome
Accession NZ_CP094133
Organism Helicobacter pylori strain Hpfe049

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPG21_RS06050 Protein ID WP_180478791.1
Coordinates 1262794..1263075 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPG21_RS06055 Protein ID WP_088297874.1
Coordinates 1263068..1263382 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG21_RS06020 (MPG21_06020) 1258022..1258962 + 941 Protein_1177 ATPase, T2SS/T4P/T4SS family -
MPG21_RS06025 (MPG21_06025) 1258959..1259414 + 456 WP_245025046.1 mobilization protein -
MPG21_RS06030 (MPG21_06030) 1259411..1259701 + 291 WP_050850784.1 hypothetical protein -
MPG21_RS06035 (MPG21_06035) 1259702..1260259 + 558 WP_245025048.1 hypothetical protein -
MPG21_RS06040 (MPG21_06040) 1260260..1261207 + 948 WP_245025050.1 type IV secretory system conjugative DNA transfer family protein -
MPG21_RS06045 (MPG21_06045) 1261192..1262475 + 1284 Protein_1182 type IV secretory system conjugative DNA transfer family protein -
MPG21_RS06050 (MPG21_06050) 1262794..1263075 - 282 WP_180478791.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MPG21_RS06055 (MPG21_06055) 1263068..1263382 - 315 WP_088297874.1 hypothetical protein Antitoxin
MPG21_RS06060 (MPG21_06060) 1263676..1265585 + 1910 Protein_1185 relaxase/mobilization nuclease domain-containing protein -
MPG21_RS06065 (MPG21_06065) 1265610..1266769 - 1160 Protein_1186 hypothetical protein -
MPG21_RS06070 (MPG21_06070) 1266801..1267085 - 285 WP_000394639.1 hypothetical protein -
MPG21_RS06075 (MPG21_06075) 1267167..1267823 - 657 Protein_1188 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10964.84 Da        Isoelectric Point: 10.0472

>T239261 WP_180478791.1 NZ_CP094133:c1263075-1262794 [Helicobacter pylori]
MLKVRTKKDFFKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRERHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T239261 NZ_LR890652:c6194-6036 [Escherichia coli]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12145.59 Da        Isoelectric Point: 5.6753

>AT239261 WP_088297874.1 NZ_CP094133:c1263382-1263068 [Helicobacter pylori]
VSNIITDYSQYNEKQLHNFLNAIERRLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239261 NZ_LR890652:c6462-6238 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGATTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References