Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1138141..1138729 Replicon chromosome
Accession NZ_CP094132
Organism Helicobacter pylori strain Hpfe051

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPG57_RS05465 Protein ID WP_140536263.1
Coordinates 1138141..1138422 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPG57_RS05470 Protein ID WP_120942310.1
Coordinates 1138415..1138729 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG57_RS05430 (MPG57_05430) 1133343..1133606 + 264 WP_000564643.1 hypothetical protein -
MPG57_RS05435 (MPG57_05435) 1133603..1133902 + 300 WP_212890959.1 hypothetical protein -
MPG57_RS05440 (MPG57_05440) 1133902..1134843 + 942 WP_154547739.1 ATPase, T2SS/T4P/T4SS family -
MPG57_RS05445 (MPG57_05445) 1134840..1135295 + 456 WP_245080535.1 mobilization protein -
MPG57_RS05450 (MPG57_05450) 1135292..1135582 + 291 WP_140526853.1 hypothetical protein -
MPG57_RS05455 (MPG57_05455) 1135583..1136139 + 557 Protein_1057 hypothetical protein -
MPG57_RS05460 (MPG57_05460) 1136140..1137867 + 1728 WP_245080537.1 type IV secretory system conjugative DNA transfer family protein -
MPG57_RS05465 (MPG57_05465) 1138141..1138422 - 282 WP_140536263.1 YafQ family addiction module toxin Toxin
MPG57_RS05470 (MPG57_05470) 1138415..1138729 - 315 WP_120942310.1 hypothetical protein Antitoxin
MPG57_RS05475 (MPG57_05475) 1139033..1140940 + 1908 WP_245080540.1 relaxase -
MPG57_RS05480 (MPG57_05480) 1140964..1142148 - 1185 WP_245080543.1 hypothetical protein -
MPG57_RS05485 (MPG57_05485) 1142180..1142464 - 285 WP_245080546.1 hypothetical protein -
MPG57_RS05490 (MPG57_05490) 1142546..1143202 - 657 WP_212890967.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cheY / flgG 1092384..1162960 70576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10904.80 Da        Isoelectric Point: 9.5726

>T239259 WP_140536263.1 NZ_CP094132:c1138422-1138141 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITENDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T239259 NZ_LR890651:c4465814-4465641 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12194.63 Da        Isoelectric Point: 5.2066

>AT239259 WP_120942310.1 NZ_CP094132:c1138729-1138415 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQWLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239259 NZ_LR890651:c4466138-4465842 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References