Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 529915..530545 Replicon chromosome
Accession NZ_CP094122
Organism Helicobacter pylori strain Hpfe058

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPG73_RS02610 Protein ID WP_245057556.1
Coordinates 530222..530545 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPG73_RS02605 Protein ID WP_024114239.1
Coordinates 529915..530229 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG73_RS02585 (MPG73_02585) 525467..526123 + 657 WP_000587395.1 ParA family protein -
MPG73_RS02590 (MPG73_02590) 526205..526489 + 285 WP_000394639.1 hypothetical protein -
MPG73_RS02595 (MPG73_02595) 526573..527685 + 1113 WP_245057548.1 hypothetical protein -
MPG73_RS02600 (MPG73_02600) 527709..529619 - 1911 WP_245057550.1 relaxase/mobilization nuclease domain-containing protein -
MPG73_RS02605 (MPG73_02605) 529915..530229 + 315 WP_024114239.1 hypothetical protein Antitoxin
MPG73_RS02610 (MPG73_02610) 530222..530545 + 324 WP_245057556.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPG73_RS02615 (MPG73_02615) 530831..532558 - 1728 WP_245057558.1 type IV secretory system conjugative DNA transfer family protein -
MPG73_RS02620 (MPG73_02620) 532559..534307 - 1749 Protein_502 DUF262 domain-containing protein -
MPG73_RS02625 (MPG73_02625) 534360..534641 - 282 WP_245057560.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12572.70 Da        Isoelectric Point: 9.9338

>T239250 WP_245057556.1 NZ_CP094122:530222-530545 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKKRSNTKKFIYNNNPC

Download         Length: 324 bp

>T239250 NZ_LR890651:1908757-1909008 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12211.64 Da        Isoelectric Point: 5.2068

>AT239250 WP_024114239.1 NZ_CP094122:529915-530229 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNTIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239250 NZ_LR890651:1909005-1909259 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References