Detailed information of TA system TA239246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 153420..154008
• Replicon: chromosome
• Accession: NZ_CP094120
• Organism: Helicobacter pylori strain Hpfe061

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: A0A6M5U7W9
• Locus tag: MPG74_RS00750
• Protein ID: WP_001917619.1
• Coordinates: 153420..153701 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPG74_RS00755
• Protein ID: WP_245069685.1
• Coordinates: 153694..154008 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG74_RS00715 (148572)	148572..148835	+	264	WP_245069676.1	hypothetical protein	-
MPG74_RS00720 (148832)	148832..149131	+	300	WP_000660136.1	hypothetical protein	-
MPG74_RS00725 (149131)	149131..150071	+	941	Protein_142	ATPase, T2SS/T4P/T4SS family	-
MPG74_RS00730 (150068)	150068..150523	+	456	WP_245069678.1	mobilization protein	-
MPG74_RS00735 (150520)	150520..150810	+	291	WP_245069680.1	hypothetical protein	-
MPG74_RS00740 (150811)	150811..151368	+	558	WP_231172052.1	hypothetical protein	-
MPG74_RS00745 (151369)	151369..153096	+	1728	WP_245069683.1	type IV secretory system conjugative DNA transfer family protein	-
MPG74_RS00750 (153420)	153420..153701	-	282	WP_001917619.1	YafQ family addiction module toxin	Toxin
MPG74_RS00755 (153694)	153694..154008	-	315	WP_245069685.1	hypothetical protein	Antitoxin
MPG74_RS00760 (154303)	154303..156213	+	1911	WP_245069687.1	relaxase/mobilization nuclease domain-containing protein	-
MPG74_RS00765 (156238)	156238..157401	-	1164	WP_245069689.1	hypothetical protein	-
MPG74_RS00770 (157433)	157433..157717	-	285	WP_000394639.1	hypothetical protein	-
MPG74_RS00775 (157799)	157799..158455	-	657	WP_245069692.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10877.77 Da
• Isoelectric Point: 9.5726

>T239246 WP_001917619.1 NZ_CP094120:c153701-153420 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239246 NZ_LR890651:c588626-588162 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12260.72 Da
• Isoelectric Point: 6.2304

>AT239246 WP_245069685.1 NZ_CP094120:c154008-153694 [Helicobacter pylori]
VSNIITDYSQYNEKQLHNFLNAIEKQWLKAERDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKNDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239246 NZ_LR890651:c588961-588626 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A6M5U7W9