Detailed information of TA system TA239238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 499854..500442
• Replicon: chromosome
• Accession: NZ_CP094111
• Organism: Helicobacter pylori strain Hpfe070

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: G2MCY5
• Locus tag: MPG22_RS02455
• Protein ID: WP_000921928.1
• Coordinates: 500161..500442 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPG22_RS02450
• Protein ID: WP_245065649.1
• Coordinates: 499854..500168 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG22_RS02430 (MPG22_02430)	495441..496043	+	603	WP_245065642.1	ParA family protein	-
MPG22_RS02435 (MPG22_02435)	496125..496409	+	285	WP_058338844.1	hypothetical protein	-
MPG22_RS02440 (MPG22_02440)	496441..497625	+	1185	WP_245065645.1	hypothetical protein	-
MPG22_RS02445 (MPG22_02445)	497649..499559	-	1911	WP_245065647.1	relaxase/mobilization nuclease domain-containing protein	-
MPG22_RS02450 (MPG22_02450)	499854..500168	+	315	WP_245065649.1	hypothetical protein	Antitoxin
MPG22_RS02455 (MPG22_02455)	500161..500442	+	282	WP_000921928.1	YafQ family addiction module toxin	Toxin
MPG22_RS02460 (MPG22_02460)	500715..502442	-	1728	WP_245065651.1	type IV secretory system conjugative DNA transfer family protein	-
MPG22_RS02465 (MPG22_02465)	502443..504197	-	1755	WP_245065653.1	DUF262 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10918.87 Da
• Isoelectric Point: 9.8257

>T239238 WP_000921928.1 NZ_CP094111:500161-500442 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239238 NZ_LR890648:c4652922-4652389 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12108.53 Da
• Isoelectric Point: 4.9439

>AT239238 WP_245065649.1 NZ_CP094111:499854-500168 [Helicobacter pylori]
MSDVITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239238 NZ_LR890648:c4653199-4652933 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: G2MCY5