Detailed information of TA system TA239234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 372019..372607
• Replicon: chromosome
• Accession: NZ_CP094107
• Organism: Helicobacter pylori strain Hpfe074

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: -
• Locus tag: MPG17_RS01845
• Protein ID: WP_245018045.1
• Coordinates: 372019..372300 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPG17_RS01850
• Protein ID: WP_245018046.1
• Coordinates: 372293..372607 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG17_RS01810 (MPG17_01810)	367220..367483	+	264	WP_245018040.1	hypothetical protein	-
MPG17_RS01815 (MPG17_01815)	367480..367779	+	300	WP_180509385.1	hypothetical protein	-
MPG17_RS01820 (MPG17_01820)	367779..368720	+	942	WP_245018041.1	ATPase, T2SS/T4P/T4SS family	-
MPG17_RS01825 (MPG17_01825)	368717..369172	+	456	WP_245018042.1	mobilization protein	-
MPG17_RS01830 (MPG17_01830)	369169..369459	+	291	WP_000159818.1	hypothetical protein	-
MPG17_RS01835 (MPG17_01835)	369460..370017	+	558	WP_245018043.1	hypothetical protein	-
MPG17_RS01840 (MPG17_01840)	370018..371745	+	1728	WP_245018044.1	type IV secretory system conjugative DNA transfer family protein	-
MPG17_RS01845 (MPG17_01845)	372019..372300	-	282	WP_245018045.1	YafQ family addiction module toxin	Toxin
MPG17_RS01850 (MPG17_01850)	372293..372607	-	315	WP_245018046.1	hypothetical protein	Antitoxin
MPG17_RS01855 (MPG17_01855)	372903..374810	+	1908	WP_245018047.1	relaxase/mobilization nuclease domain-containing protein	-
MPG17_RS01860 (MPG17_01860)	374835..375998	-	1164	WP_245018048.1	hypothetical protein	-
MPG17_RS01865 (MPG17_01865)	376030..376314	-	285	WP_245018049.1	hypothetical protein	-
MPG17_RS01870 (MPG17_01870)	376388..377047	-	660	WP_245018050.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10902.83 Da
• Isoelectric Point: 9.8257

>T239234 WP_245018045.1 NZ_CP094107:c372300-372019 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSEPFKK

Nucleotide

• Length: 282 bp

>T239234 NZ_LR890648:1874483-1874585 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12139.55 Da
• Isoelectric Point: 5.2066

>AT239234 WP_245018046.1 NZ_CP094107:c372607-372293 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNTIEKQLLKAEGDKNKATKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239234 NZ_LR890648:c1874592-1874447 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT