Detailed information of TA system TA239229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 1428695..1429283
• Replicon: chromosome
• Accession: NZ_CP094101
• Organism: Helicobacter pylori strain Hpfe079

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: -
• Locus tag: MPF96_RS06885
• Protein ID: WP_220901806.1
• Coordinates: 1428695..1428976 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPF96_RS06890
• Protein ID: WP_140540393.1
• Coordinates: 1428969..1429283 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF96_RS06850 (MPF96_06850)	1423842..1424105	+	264	WP_245048853.1	hypothetical protein	-
MPF96_RS06855 (MPF96_06855)	1424102..1424401	+	300	WP_180509385.1	hypothetical protein	-
MPF96_RS06860 (MPF96_06860)	1424401..1425343	+	943	Protein_1338	ATPase, T2SS/T4P/T4SS family	-
MPF96_RS06865 (MPF96_06865)	1425340..1425795	+	456	WP_245048854.1	mobilization protein	-
MPF96_RS06870 (MPF96_06870)	1425792..1426082	+	291	WP_120872358.1	hypothetical protein	-
MPF96_RS06875 (MPF96_06875)	1426083..1426640	+	558	WP_245048855.1	hypothetical protein	-
MPF96_RS06880 (MPF96_06880)	1426641..1428368	+	1728	WP_245048856.1	type IV secretory system conjugative DNA transfer family protein	-
MPF96_RS06885 (MPF96_06885)	1428695..1428976	-	282	WP_220901806.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MPF96_RS06890 (MPF96_06890)	1428969..1429283	-	315	WP_140540393.1	hypothetical protein	Antitoxin
MPF96_RS06895 (MPF96_06895)	1429579..1431490	+	1912	Protein_1345	relaxase/mobilization nuclease domain-containing protein	-
MPF96_RS06900 (MPF96_06900)	1431514..1432626	-	1113	WP_245049901.1	hypothetical protein	-
MPF96_RS06905 (MPF96_06905)	1432708..1432992	-	285	WP_154410086.1	hypothetical protein	-
MPF96_RS06910 (MPF96_06910)	1433074..1433730	-	657	WP_245048857.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	ureB / ureI / ureE / ureF / ureG / ureH	1403592..1508028	104436

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10875.80 Da
• Isoelectric Point: 9.5726

>T239229 WP_220901806.1 NZ_CP094101:c1428976-1428695 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVVSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239229 NZ_LR890643:c5144864-5144481 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12109.52 Da
• Isoelectric Point: 5.2066

>AT239229 WP_140540393.1 NZ_CP094101:c1429283-1428969 [Helicobacter pylori]
MSNITTDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239229 NZ_LR890643:c5145106-5144864 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA