239215

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 755398..755986 Replicon chromosome
Accession NZ_CP094090
Organism Helicobacter pylori strain Hpfe089

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPF90_RS03550 Protein ID WP_079304372.1
Coordinates 755705..755986 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPF90_RS03545 Protein ID WP_120942310.1
Coordinates 755398..755712 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF90_RS03525 (750954) 750954..751610 + 657 WP_000587395.1 ParA family protein -
MPF90_RS03530 (751692) 751692..751976 + 285 WP_000394639.1 hypothetical protein -
MPF90_RS03535 (752008) 752008..753171 + 1164 WP_245023381.1 hypothetical protein -
MPF90_RS03540 (753195) 753195..755104 - 1910 Protein_679 relaxase/mobilization nuclease domain-containing protein -
MPF90_RS03545 (755398) 755398..755712 + 315 WP_120942310.1 hypothetical protein Antitoxin
MPF90_RS03550 (755705) 755705..755986 + 282 WP_079304372.1 YafQ family addiction module toxin Toxin
MPF90_RS03555 (756269) 756269..758001 - 1733 Protein_682 type IV secretory system conjugative DNA transfer family protein -
MPF90_RS03560 (757995) 757995..758551 - 557 Protein_683 hypothetical protein -
MPF90_RS03565 (758552) 758552..758843 - 292 Protein_684 hypothetical protein -
MPF90_RS03570 (758840) 758840..759295 - 456 WP_245023382.1 mobilization protein -
MPF90_RS03575 (759292) 759292..760233 - 942 WP_015086303.1 ATPase, T2SS/T4P/T4SS family -
MPF90_RS03580 (760233) 760233..760532 - 300 WP_000660135.1 hypothetical protein -
MPF90_RS03585 (760529) 760529..760793 - 265 Protein_688 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vacA / cds6 / cag1 / cag3 / virB1 / virD4 / virB11 / cagZ / virB10/cagY / virB9/cagX / virB6/cagW / virB8/cagV / cagU / virB7/cagT / cagS / cagQ / cagM / cagN / virB5/cagL / cagI / cagH / cagG / cagF / virB4/cagE / cagD / virB2/cagC / cagA / fliN / cheV3 / flaA / hopH / futA / wbpB / fliP / flgR / hopH / sabA/hopP 571970..927177 355207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10971.87 Da        Isoelectric Point: 10.0472

>T239215 WP_079304372.1 NZ_CP094090:755705-755986 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITENDVTSVVDRLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T239215 NZ_LR890641:c86192-85710 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12194.63 Da        Isoelectric Point: 5.2066

>AT239215 WP_120942310.1 NZ_CP094090:755398-755712 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQWLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239215 NZ_LR890641:c86446-86180 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References