Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 354343..354931 Replicon chromosome
Accession NZ_CP094082
Organism Helicobacter pylori strain Hpfe097

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPG63_RS01770 Protein ID WP_156584260.1
Coordinates 354650..354931 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPG63_RS01765 Protein ID WP_245047578.1
Coordinates 354343..354657 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG63_RS01745 (MPG63_01745) 349915..350571 + 657 WP_245047570.1 ParA family protein -
MPG63_RS01750 (MPG63_01750) 350653..350937 + 285 WP_231200543.1 hypothetical protein -
MPG63_RS01755 (MPG63_01755) 350969..352132 + 1164 WP_245047572.1 hypothetical protein -
MPG63_RS01760 (MPG63_01760) 352157..354067 - 1911 WP_245047577.1 relaxase/mobilization nuclease domain-containing protein -
MPG63_RS01765 (MPG63_01765) 354343..354657 + 315 WP_245047578.1 hypothetical protein Antitoxin
MPG63_RS01770 (MPG63_01770) 354650..354931 + 282 WP_156584260.1 YafQ family addiction module toxin Toxin
MPG63_RS01775 (MPG63_01775) 355259..356986 - 1728 WP_245047579.1 type IV secretory system conjugative DNA transfer family protein -
MPG63_RS01780 (MPG63_01780) 356987..357544 - 558 WP_245047580.1 hypothetical protein -
MPG63_RS01785 (MPG63_01785) 357545..357835 - 291 WP_245047582.1 hypothetical protein -
MPG63_RS01790 (MPG63_01790) 357832..358287 - 456 WP_245047584.1 mobilization protein -
MPG63_RS01795 (MPG63_01795) 358284..359224 - 941 Protein_346 ATPase, T2SS/T4P/T4SS family -
MPG63_RS01800 (MPG63_01800) 359224..359522 - 299 Protein_347 hypothetical protein -
MPG63_RS01805 (MPG63_01805) 359519..359782 - 264 WP_180433943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gluP 310313..371618 61305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10956.90 Da        Isoelectric Point: 10.0472

>T239207 WP_156584260.1 NZ_CP094082:354650-354931 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVVSIVDRLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T239207 NZ_LR890640:c3241550-3241266 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12280.75 Da        Isoelectric Point: 5.7657

>AT239207 WP_245047578.1 NZ_CP094082:354343-354657 [Helicobacter pylori]
MSNIITDYSQYNEKQLRNFLNAIEKQWLKAERDKNKAIKKIQECELQEQVIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239207 NZ_LR890640:c3241782-3241540 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References