Detailed information of TA system TA239204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 150350..150938
• Replicon: chromosome
• Accession: NZ_CP094080
• Organism: Helicobacter pylori strain Hpfe099

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: M3P300
• Locus tag: MPG38_RS00690
• Protein ID: WP_000921941.1
• Coordinates: 150350..150631 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPG38_RS00695
• Protein ID: WP_120942310.1
• Coordinates: 150624..150938 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG38_RS00655 (145550)	145550..145813	+	264	WP_000564648.1	hypothetical protein	-
MPG38_RS00660 (145810)	145810..146109	+	300	WP_245101300.1	hypothetical protein	-
MPG38_RS00665 (146109)	146109..147050	+	942	WP_245101301.1	ATPase, T2SS/T4P/T4SS family	-
MPG38_RS00670 (147047)	147047..147502	+	456	WP_025276161.1	hypothetical protein	-
MPG38_RS00675 (147499)	147499..147786	+	288	WP_245101302.1	hypothetical protein	-
MPG38_RS00680 (147792)	147792..148348	+	557	Protein_132	hypothetical protein	-
MPG38_RS00685 (148349)	148349..150076	+	1728	WP_245101303.1	type IV secretory system conjugative DNA transfer family protein	-
MPG38_RS00690 (150350)	150350..150631	-	282	WP_000921941.1	YafQ family addiction module toxin	Toxin
MPG38_RS00695 (150624)	150624..150938	-	315	WP_120942310.1	hypothetical protein	Antitoxin
MPG38_RS00700 (151234)	151234..153144	+	1911	WP_245101304.1	relaxase/mobilization nuclease domain-containing protein	-
MPG38_RS00705 (153168)	153168..154349	-	1182	WP_245101305.1	hypothetical protein	-
MPG38_RS00710 (154381)	154381..154665	-	285	WP_050851442.1	hypothetical protein	-
MPG38_RS00715 (154737)	154737..155402	-	666	WP_245101306.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10891.80 Da
• Isoelectric Point: 9.5726

>T239204 WP_000921941.1 NZ_CP094080:c150631-150350 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239204 NZ_LR890640:c2403020-2402703 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12194.63 Da
• Isoelectric Point: 5.2066

>AT239204 WP_120942310.1 NZ_CP094080:c150938-150624 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQWLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239204 NZ_LR890640:c2402710-2402423 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACGTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: M3P300