239201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 512769..513357 Replicon chromosome
Accession NZ_CP094076
Organism Helicobacter pylori strain Hpfe102

Toxin (Protein)


Gene name TfiT Uniprot ID K2LF18
Locus tag MPG56_RS02530 Protein ID WP_000921926.1
Coordinates 512769..513050 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPG56_RS02535 Protein ID WP_245044150.1
Coordinates 513043..513357 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG56_RS02495 (MPG56_02495) 507970..508233 + 264 WP_029650283.1 hypothetical protein -
MPG56_RS02500 (MPG56_02500) 508230..508529 + 300 WP_000660136.1 hypothetical protein -
MPG56_RS02505 (MPG56_02505) 508529..509470 + 942 WP_154497724.1 ATPase, T2SS/T4P/T4SS family -
MPG56_RS02510 (MPG56_02510) 509467..509922 + 456 WP_025276161.1 hypothetical protein -
MPG56_RS02515 (MPG56_02515) 509919..510209 + 291 WP_000159818.1 hypothetical protein -
MPG56_RS02520 (MPG56_02520) 510210..510767 + 558 WP_245044146.1 hypothetical protein -
MPG56_RS02525 (MPG56_02525) 510768..512495 + 1728 WP_245044148.1 type IV secretory system conjugative DNA transfer family protein -
MPG56_RS02530 (MPG56_02530) 512769..513050 - 282 WP_000921926.1 YafQ family addiction module toxin Toxin
MPG56_RS02535 (MPG56_02535) 513043..513357 - 315 WP_245044150.1 hypothetical protein Antitoxin
MPG56_RS02540 (MPG56_02540) 513652..515558 + 1907 Protein_486 relaxase/mobilization nuclease domain-containing protein -
MPG56_RS02545 (MPG56_02545) 515583..516767 - 1185 WP_245044152.1 hypothetical protein -
MPG56_RS02550 (MPG56_02550) 516799..517083 - 285 WP_245044154.1 hypothetical protein -
MPG56_RS02555 (MPG56_02555) 517165..517820 - 656 Protein_489 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 456656..539638 82982


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10932.89 Da        Isoelectric Point: 9.8257

>T239201 WP_000921926.1 NZ_CP094076:c513050-512769 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDVTSIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T239201 NZ_LR890636:69663-69812 [Klebsiella pneumoniae]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12237.68 Da        Isoelectric Point: 5.6761

>AT239201 WP_245044150.1 NZ_CP094076:c513357-513043 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIERRLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239201 NZ_LR890636:c69618-69559 [Klebsiella pneumoniae]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2LF18

Antitoxin

Source ID Structure

References