239199

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1546906..1547494 Replicon chromosome
Accession NZ_CP094073
Organism Helicobacter pylori strain Hpfe104

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPG32_RS07410 Protein ID WP_180653715.1
Coordinates 1546906..1547187 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPG32_RS07415 Protein ID WP_245019597.1
Coordinates 1547180..1547494 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPG32_RS07395 (1542578) 1542578..1544482 - 1905 Protein_1437 HsdR family type I site-specific deoxyribonuclease -
MPG32_RS07400 (1544467) 1544467..1544906 + 440 Protein_1438 hypothetical protein -
MPG32_RS07405 (1544907) 1544907..1546634 + 1728 WP_245019596.1 type IV secretory system conjugative DNA transfer family protein -
MPG32_RS07410 (1546906) 1546906..1547187 - 282 WP_180653715.1 YafQ family addiction module toxin Toxin
MPG32_RS07415 (1547180) 1547180..1547494 - 315 WP_245019597.1 hypothetical protein Antitoxin
MPG32_RS07420 (1547779) 1547779..1549689 + 1911 Protein_1442 relaxase/mobilization nuclease domain-containing protein -
MPG32_RS07425 (1549713) 1549713..1550846 - 1134 WP_245020027.1 hypothetical protein -
MPG32_RS07430 (1550930) 1550930..1551214 - 285 WP_000394639.1 hypothetical protein -
MPG32_RS07435 (1551296) 1551296..1551439 - 144 Protein_1445 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10905.83 Da        Isoelectric Point: 9.5726

>T239199 WP_180653715.1 NZ_CP094073:c1547187-1546906 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELI
LLRLDTHSELFKK

Download         Length: 282 bp

>T239199 NZ_LR890634:c14275-13925 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12219.77 Da        Isoelectric Point: 6.7134

>AT239199 WP_245019597.1 NZ_CP094073:c1547494-1547180 [Helicobacter pylori]
MSNIITDYSQYNKKQLHNFLNAIEKQLLKAERDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT239199 NZ_LR890634:c13920-13618 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References