Detailed information of TA system TA239197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 350847..351435
• Replicon: chromosome
• Accession: NZ_CP094071
• Organism: Helicobacter pylori strain Hpfe106

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: Q6RWC1
• Locus tag: MPG62_RS01725
• Protein ID: WP_000921939.1
• Coordinates: 351154..351435 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPG62_RS01720
• Protein ID: WP_245099611.1
• Coordinates: 350847..351161 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG62_RS01700 (MPG62_01700)	346399..347055	+	657	WP_000587395.1	ParA family protein	-
MPG62_RS01705 (MPG62_01705)	347137..347421	+	285	WP_000394639.1	hypothetical protein	-
MPG62_RS01710 (MPG62_01710)	347453..348616	+	1164	WP_245099609.1	hypothetical protein	-
MPG62_RS01715 (MPG62_01715)	348641..350551	-	1911	Protein_331	relaxase/mobilization nuclease domain-containing protein	-
MPG62_RS01720 (MPG62_01720)	350847..351161	+	315	WP_245099611.1	hypothetical protein	Antitoxin
MPG62_RS01725 (MPG62_01725)	351154..351435	+	282	WP_000921939.1	YafQ family addiction module toxin	Toxin
MPG62_RS01730 (MPG62_01730)	351710..353437	-	1728	WP_245099613.1	type IV secretory system conjugative DNA transfer family protein	-
MPG62_RS01735 (MPG62_01735)	353438..353995	-	558	WP_245099615.1	hypothetical protein	-
MPG62_RS01740 (MPG62_01740)	353996..354286	-	291	WP_245099617.1	hypothetical protein	-
MPG62_RS01745 (MPG62_01745)	354283..354738	-	456	WP_231173204.1	mobilization protein	-
MPG62_RS01750 (MPG62_01750)	354735..355676	-	942	WP_245099618.1	CpaF/VirB11 family protein	-
MPG62_RS01755 (MPG62_01755)	355676..355975	-	300	WP_000660136.1	hypothetical protein	-
MPG62_RS01760 (MPG62_01760)	355972..356235	-	264	WP_245099620.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10905.83 Da
• Isoelectric Point: 9.5726

>T239197 WP_000921939.1 NZ_CP094071:351154-351435 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239197 NZ_LR890632:5082896-5083213 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12224.68 Da
• Isoelectric Point: 5.6665

>AT239197 WP_245099611.1 NZ_CP094071:350847-351161 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIVSKDDPE
YDVSFGDFNNFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239197 NZ_LR890632:5083206-5083493 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: A0A2X4ZKZ6