Detailed information of TA system TA239196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 1430032..1430620
• Replicon: chromosome
• Accession: NZ_CP094070
• Organism: Helicobacter pylori strain Hpfe107

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: -
• Locus tag: MPG33_RS06885
• Protein ID: WP_220901806.1
• Coordinates: 1430032..1430313 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPG33_RS06890
• Protein ID: WP_140540393.1
• Coordinates: 1430306..1430620 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG33_RS06850 (MPG33_06850)	1425179..1425442	+	264	WP_245048853.1	hypothetical protein	-
MPG33_RS06855 (MPG33_06855)	1425439..1425738	+	300	WP_180509385.1	hypothetical protein	-
MPG33_RS06860 (MPG33_06860)	1425738..1426680	+	943	Protein_1340	ATPase, T2SS/T4P/T4SS family	-
MPG33_RS06865 (MPG33_06865)	1426677..1427132	+	456	WP_245048854.1	mobilization protein	-
MPG33_RS06870 (MPG33_06870)	1427129..1427419	+	291	WP_120872358.1	hypothetical protein	-
MPG33_RS06875 (MPG33_06875)	1427420..1427977	+	558	WP_245048855.1	hypothetical protein	-
MPG33_RS06880 (MPG33_06880)	1427978..1429705	+	1728	WP_245062600.1	type IV secretory system conjugative DNA transfer family protein	-
MPG33_RS06885 (MPG33_06885)	1430032..1430313	-	282	WP_220901806.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MPG33_RS06890 (MPG33_06890)	1430306..1430620	-	315	WP_140540393.1	hypothetical protein	Antitoxin
MPG33_RS06895 (MPG33_06895)	1430916..1432827	+	1912	Protein_1347	relaxase/mobilization nuclease domain-containing protein	-
MPG33_RS06900 (MPG33_06900)	1432851..1433963	-	1113	WP_245063310.1	hypothetical protein	-
MPG33_RS06905 (MPG33_06905)	1434045..1434329	-	285	WP_154410086.1	hypothetical protein	-
MPG33_RS06910 (MPG33_06910)	1434411..1435067	-	657	WP_245048857.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	ureB / ureI / ureE / ureF / ureG / ureH	1404954..1507924	102970

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10875.80 Da
• Isoelectric Point: 9.5726

>T239196 WP_220901806.1 NZ_CP094070:c1430313-1430032 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVVSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239196 NZ_LR890632:c4952961-4952743 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12109.52 Da
• Isoelectric Point: 5.2066

>AT239196 WP_140540393.1 NZ_CP094070:c1430620-1430306 [Helicobacter pylori]
MSNITTDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239196 NZ_LR890632:c4953362-4952988 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG