Detailed information of TA system TA239193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 502867..503455
• Replicon: chromosome
• Accession: NZ_CP094067
• Organism: Helicobacter pylori strain Hpfe108

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: -
• Locus tag: MPG11_RS02495
• Protein ID: WP_088297872.1
• Coordinates: 503174..503455 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: T5DIX9
• Locus tag: MPG11_RS02490
• Protein ID: WP_000065296.1
• Coordinates: 502867..503181 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPG11_RS02470 (MPG11_02470)	498395..499055	+	661	Protein_474	ParA family protein	-
MPG11_RS02475 (MPG11_02475)	499137..499421	+	285	WP_245052941.1	hypothetical protein	-
MPG11_RS02480 (MPG11_02480)	499453..500637	+	1185	WP_245052943.1	hypothetical protein	-
MPG11_RS02485 (MPG11_02485)	500662..502572	-	1911	WP_245049757.1	relaxase/mobilization nuclease domain-containing protein	-
MPG11_RS02490 (MPG11_02490)	502867..503181	+	315	WP_000065296.1	hypothetical protein	Antitoxin
MPG11_RS02495 (MPG11_02495)	503174..503455	+	282	WP_088297872.1	YafQ family addiction module toxin	Toxin
MPG11_RS02500 (MPG11_02500)	503729..505456	-	1728	WP_245052945.1	type IV secretory system conjugative DNA transfer family protein	-
MPG11_RS02505 (MPG11_02505)	505457..507205	-	1749	WP_245052947.1	DUF262 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10888.84 Da
• Isoelectric Point: 9.8257

>T239193 WP_088297872.1 NZ_CP094067:503174-503455 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDVASVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239193 NZ_LR890632:3702496-3702879 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12137.57 Da
• Isoelectric Point: 5.2066

>AT239193 WP_000065296.1 NZ_CP094067:502867-503181 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Nucleotide

• Length: 315 bp

>AT239193 NZ_LR890632:3702254-3702496 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: T5DIX9