Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ(toxin) |
| Location | 754607..755195 | Replicon | chromosome |
| Accession | NZ_CP094061 | ||
| Organism | Helicobacter pylori strain Hpfe120 | ||
Toxin (Protein)
| Gene name | TfiT | Uniprot ID | A0A6M5U7W9 |
| Locus tag | MPG58_RS03525 | Protein ID | WP_001917619.1 |
| Coordinates | 754914..755195 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | TfiA | Uniprot ID | - |
| Locus tag | MPG58_RS03520 | Protein ID | WP_033123190.1 |
| Coordinates | 754607..754921 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPG58_RS03500 (MPG58_03500) | 750164..750818 | + | 655 | Protein_671 | ParA family protein | - |
| MPG58_RS03505 (MPG58_03505) | 750900..751184 | + | 285 | WP_000394639.1 | hypothetical protein | - |
| MPG58_RS03510 (MPG58_03510) | 751216..752377 | + | 1162 | Protein_673 | hypothetical protein | - |
| MPG58_RS03515 (MPG58_03515) | 752401..754312 | - | 1912 | Protein_674 | relaxase/mobilization nuclease domain-containing protein | - |
| MPG58_RS03520 (MPG58_03520) | 754607..754921 | + | 315 | WP_033123190.1 | hypothetical protein | Antitoxin |
| MPG58_RS03525 (MPG58_03525) | 754914..755195 | + | 282 | WP_001917619.1 | YafQ family addiction module toxin | Toxin |
| MPG58_RS03530 (MPG58_03530) | 755520..757252 | - | 1733 | Protein_677 | type IV secretory system conjugative DNA transfer family protein | - |
| MPG58_RS03535 (MPG58_03535) | 757253..757810 | - | 558 | WP_245012179.1 | hypothetical protein | - |
| MPG58_RS03540 (MPG58_03540) | 757811..758101 | - | 291 | WP_245012180.1 | hypothetical protein | - |
| MPG58_RS03545 (MPG58_03545) | 758098..758553 | - | 456 | WP_245012181.1 | mobilization protein | - |
| MPG58_RS03550 (MPG58_03550) | 758550..759491 | - | 942 | WP_245012182.1 | ATPase, T2SS/T4P/T4SS family | - |
| MPG58_RS03555 (MPG58_03555) | 759491..759790 | - | 300 | WP_245012183.1 | hypothetical protein | - |
| MPG58_RS03560 (MPG58_03560) | 759787..760050 | - | 264 | WP_245012184.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | cds6 / cag1 / cag3 / virB1 / virD4 / virB11 / cagZ / virB10/cagY / virB9/cagX / virB6/cagW / virB8/cagV / cagU / virB7/cagT / cagS / cagQ / cagP / cagM / cagN / virB5/cagL / cagI / cagH / cagG / cagF / virB4/cagE / cagD / virB2/cagC / cagA / fliN / cheV3 / flaA / hopH | 602002..798084 | 196082 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10877.77 Da Isoelectric Point: 9.5726
>T239182 WP_001917619.1 NZ_CP094061:754914-755195 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEVKKQENELV
LLRLDTHSELFKK
Download Length: 282 bp
>T239182 NZ_LR890624:c5160365-5159982 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCCTCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCCTCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12293.76 Da Isoelectric Point: 5.6753
>AT239182 WP_033123190.1 NZ_CP094061:754607-754921 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQWLKAERDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA
MSNIITDYSQYNEKQLHNFLNAIEKQWLKAERDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA
Download Length: 315 bp
>AT239182 NZ_LR890624:c5160607-5160365 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|