Detailed information of TA system TA239174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 134435..135023
• Replicon: chromosome
• Accession: NZ_CP094052
• Organism: Helicobacter pylori strain Hpfe126

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: -
• Locus tag: MPF87_RS00645
• Protein ID: WP_000921942.1
• Coordinates: 134435..134716 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: MPF87_RS00650
• Protein ID: WP_245012715.1
• Coordinates: 134709..135023 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF87_RS00635 (MPF87_00635)	132006..132437	+	432	Protein_122	hypothetical protein	-
MPF87_RS00640 (MPF87_00640)	132438..134165	+	1728	WP_245012714.1	type IV secretory system conjugative DNA transfer family protein	-
MPF87_RS00645 (MPF87_00645)	134435..134716	-	282	WP_000921942.1	YafQ family addiction module toxin	Toxin
MPF87_RS00650 (MPF87_00650)	134709..135023	-	315	WP_245012715.1	hypothetical protein	Antitoxin
MPF87_RS00655 (MPF87_00655)	135318..137228	+	1911	WP_245012716.1	relaxase/mobilization nuclease domain-containing protein	-
MPF87_RS00660 (MPF87_00660)	137253..137819	-	567	Protein_127	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10944.85 Da
• Isoelectric Point: 10.0472

>T239174 WP_000921942.1 NZ_CP094052:c134716-134435 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDRLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T239174 NZ_LR890624:321921-322289 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12142.58 Da
• Isoelectric Point: 5.2248

>AT239174 WP_245012715.1 NZ_CP094052:c135023-134709 [Helicobacter pylori]
VSNIITDYSQYNEKQLHNFLNAIEKQLFKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERRNA

Nucleotide

• Length: 315 bp

>AT239174 NZ_LR890624:321703-321924 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA