Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 134435..135023 Replicon chromosome
Accession NZ_CP094052
Organism Helicobacter pylori strain Hpfe126

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag MPF87_RS00645 Protein ID WP_000921942.1
Coordinates 134435..134716 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag MPF87_RS00650 Protein ID WP_245012715.1
Coordinates 134709..135023 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPF87_RS00635 (MPF87_00635) 132006..132437 + 432 Protein_122 hypothetical protein -
MPF87_RS00640 (MPF87_00640) 132438..134165 + 1728 WP_245012714.1 type IV secretory system conjugative DNA transfer family protein -
MPF87_RS00645 (MPF87_00645) 134435..134716 - 282 WP_000921942.1 YafQ family addiction module toxin Toxin
MPF87_RS00650 (MPF87_00650) 134709..135023 - 315 WP_245012715.1 hypothetical protein Antitoxin
MPF87_RS00655 (MPF87_00655) 135318..137228 + 1911 WP_245012716.1 relaxase/mobilization nuclease domain-containing protein -
MPF87_RS00660 (MPF87_00660) 137253..137819 - 567 Protein_127 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10944.85 Da        Isoelectric Point: 10.0472

>T239174 WP_000921942.1 NZ_CP094052:c134716-134435 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDRLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T239174 NZ_LR890624:321921-322289 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12142.58 Da        Isoelectric Point: 5.2248

>AT239174 WP_245012715.1 NZ_CP094052:c135023-134709 [Helicobacter pylori]
VSNIITDYSQYNEKQLHNFLNAIEKQLFKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERRNA

Download         Length: 315 bp

>AT239174 NZ_LR890624:321703-321924 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References