Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5389287..5389882 Replicon chromosome
Accession NZ_CP093967
Organism Pseudomonas aeruginosa strain NY4605

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MO986_RS24980 Protein ID WP_071538299.1
Coordinates 5389604..5389882 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MO986_RS24975 Protein ID WP_003123432.1
Coordinates 5389287..5389592 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO986_RS24955 (MO986_24950) 5384634..5384906 - 273 WP_128723119.1 DNA-binding protein -
MO986_RS24960 (MO986_24955) 5385018..5385290 + 273 WP_058137854.1 hypothetical protein -
MO986_RS24965 (MO986_24960) 5385450..5387219 + 1770 WP_128723118.1 DGQHR domain-containing protein -
MO986_RS24970 (MO986_24965) 5387247..5388296 - 1050 WP_225024466.1 site-specific DNA-methyltransferase -
MO986_RS24975 (MO986_24970) 5389287..5389592 - 306 WP_003123432.1 HigA family addiction module antitoxin Antitoxin
MO986_RS24980 (MO986_24975) 5389604..5389882 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MO986_RS24985 (MO986_24980) 5389935..5390063 - 129 Protein_4948 integrase -
MO986_RS24990 (MO986_24985) 5390211..5392439 + 2229 WP_003113525.1 TonB-dependent receptor -
MO986_RS24995 (MO986_24990) 5392509..5393156 - 648 WP_003095021.1 carbonate dehydratase -
MO986_RS25000 (MO986_24995) 5393218..5394456 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T239169 WP_071538299.1 NZ_CP093967:c5389882-5389604 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T239169 NZ_LR890621:c20816-20511 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTCTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT239169 WP_003123432.1 NZ_CP093967:c5389592-5389287 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT239169 NZ_LR890621:c21036-20818 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGGCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCCGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References