Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 61163..61698 | Replicon | plasmid pNY11067-1 |
Accession | NZ_CP093954 | ||
Organism | Enterococcus faecium strain NY11067 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | Q3Y221 |
Locus tag | MPM51_RS14350 | Protein ID | WP_002305108.1 |
Coordinates | 61426..61698 (+) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A133CED7 |
Locus tag | MPM51_RS14345 | Protein ID | WP_002303154.1 |
Coordinates | 61163..61426 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MPM51_RS14320 (MPM51_14320) | 57166..57438 | + | 273 | WP_002305107.1 | DUF3884 family protein | - |
MPM51_RS14325 (MPM51_14325) | 57459..58358 | + | 900 | WP_002303235.1 | aldose 1-epimerase family protein | - |
MPM51_RS14335 (MPM51_14335) | 60072..60635 | + | 564 | Protein_59 | IS6-like element ISS1N family transposase | - |
MPM51_RS14340 (MPM51_14340) | 60734..61057 | + | 324 | WP_224453712.1 | hypothetical protein | - |
MPM51_RS14345 (MPM51_14345) | 61163..61426 | + | 264 | WP_002303154.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
MPM51_RS14350 (MPM51_14350) | 61426..61698 | + | 273 | WP_002305108.1 | Txe/YoeB family addiction module toxin | Toxin |
MPM51_RS14355 (MPM51_14355) | 61775..62104 | + | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
MPM51_RS14360 (MPM51_14360) | 62094..62381 | + | 288 | WP_002300557.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
MPM51_RS14365 (MPM51_14365) | 62667..63524 | + | 858 | WP_002292680.1 | ParA family protein | - |
MPM51_RS14370 (MPM51_14370) | 63525..64073 | + | 549 | WP_002292681.1 | hypothetical protein | - |
MPM51_RS14375 (MPM51_14375) | 64370..65317 | - | 948 | WP_002303155.1 | sugar-binding domain-containing protein | - |
MPM51_RS14380 (MPM51_14380) | 65505..66692 | + | 1188 | WP_002303156.1 | NADP-dependent malic enzyme | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..211188 | 211188 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10806.28 Da Isoelectric Point: 9.9080
>T239135 WP_002305108.1 NZ_CP093954:61426-61698 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T239135 NZ_LR890607:c87433-87275 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 88 a.a. Molecular weight: 9886.16 Da Isoelectric Point: 4.5370
>AT239135 WP_002303154.1 NZ_CP093954:61163-61426 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT239135 NZ_LR890607:c87701-87477 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A133CER3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A133CED7 |