Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 61163..61698 Replicon plasmid pNY11067-1
Accession NZ_CP093954
Organism Enterococcus faecium strain NY11067

Toxin (Protein)


Gene name yoeB Uniprot ID Q3Y221
Locus tag MPM51_RS14350 Protein ID WP_002305108.1
Coordinates 61426..61698 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A133CED7
Locus tag MPM51_RS14345 Protein ID WP_002303154.1
Coordinates 61163..61426 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPM51_RS14320 (MPM51_14320) 57166..57438 + 273 WP_002305107.1 DUF3884 family protein -
MPM51_RS14325 (MPM51_14325) 57459..58358 + 900 WP_002303235.1 aldose 1-epimerase family protein -
MPM51_RS14335 (MPM51_14335) 60072..60635 + 564 Protein_59 IS6-like element ISS1N family transposase -
MPM51_RS14340 (MPM51_14340) 60734..61057 + 324 WP_224453712.1 hypothetical protein -
MPM51_RS14345 (MPM51_14345) 61163..61426 + 264 WP_002303154.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MPM51_RS14350 (MPM51_14350) 61426..61698 + 273 WP_002305108.1 Txe/YoeB family addiction module toxin Toxin
MPM51_RS14355 (MPM51_14355) 61775..62104 + 330 WP_002292678.1 AbrB family transcriptional regulator -
MPM51_RS14360 (MPM51_14360) 62094..62381 + 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
MPM51_RS14365 (MPM51_14365) 62667..63524 + 858 WP_002292680.1 ParA family protein -
MPM51_RS14370 (MPM51_14370) 63525..64073 + 549 WP_002292681.1 hypothetical protein -
MPM51_RS14375 (MPM51_14375) 64370..65317 - 948 WP_002303155.1 sugar-binding domain-containing protein -
MPM51_RS14380 (MPM51_14380) 65505..66692 + 1188 WP_002303156.1 NADP-dependent malic enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..211188 211188


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10806.28 Da        Isoelectric Point: 9.9080

>T239135 WP_002305108.1 NZ_CP093954:61426-61698 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T239135 NZ_LR890607:c87433-87275 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9886.16 Da        Isoelectric Point: 4.5370

>AT239135 WP_002303154.1 NZ_CP093954:61163-61426 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT239135 NZ_LR890607:c87701-87477 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133CER3

Antitoxin

Source ID Structure
AlphaFold DB A0A133CED7

References