Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 154992..155527 | Replicon | plasmid pNY11066-1 |
Accession | NZ_CP093948 | ||
Organism | Enterococcus faecium strain NY11066 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | Q3Y221 |
Locus tag | MPL63_RS15120 | Protein ID | WP_002305108.1 |
Coordinates | 154992..155264 (-) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A133CED7 |
Locus tag | MPL63_RS15125 | Protein ID | WP_002303154.1 |
Coordinates | 155264..155527 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MPL63_RS15090 (MPL63_15090) | 149998..151185 | - | 1188 | WP_002303156.1 | NADP-dependent malic enzyme | - |
MPL63_RS15095 (MPL63_15095) | 151373..152320 | + | 948 | WP_002303155.1 | sugar-binding domain-containing protein | - |
MPL63_RS15100 (MPL63_15100) | 152617..153165 | - | 549 | WP_002292681.1 | hypothetical protein | - |
MPL63_RS15105 (MPL63_15105) | 153166..154023 | - | 858 | WP_002292680.1 | ParA family protein | - |
MPL63_RS15110 (MPL63_15110) | 154309..154596 | - | 288 | WP_002300557.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
MPL63_RS15115 (MPL63_15115) | 154586..154915 | - | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
MPL63_RS15120 (MPL63_15120) | 154992..155264 | - | 273 | WP_002305108.1 | Txe/YoeB family addiction module toxin | Toxin |
MPL63_RS15125 (MPL63_15125) | 155264..155527 | - | 264 | WP_002303154.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
MPL63_RS15130 (MPL63_15130) | 155633..155956 | - | 324 | WP_224453712.1 | hypothetical protein | - |
MPL63_RS15135 (MPL63_15135) | 156055..156618 | - | 564 | Protein_160 | IS6-like element ISS1N family transposase | - |
MPL63_RS15140 (MPL63_15140) | 156698..157860 | + | 1163 | WP_112020409.1 | IS3 family transposase | - |
MPL63_RS15145 (MPL63_15145) | 158332..159231 | - | 900 | WP_002303235.1 | aldose 1-epimerase family protein | - |
MPL63_RS15150 (MPL63_15150) | 159252..159524 | - | 273 | WP_002305107.1 | DUF3884 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..210381 | 210381 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10806.28 Da Isoelectric Point: 9.9080
>T239130 WP_002305108.1 NZ_CP093948:c155264-154992 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T239130 NZ_LR890606:c4159162-4158788 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9886.16 Da Isoelectric Point: 4.5370
>AT239130 WP_002303154.1 NZ_CP093948:c155527-155264 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT239130 NZ_LR890606:c4159620-4159252 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCTCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCTCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A133CER3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A133CED7 |