Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2526509..2526693 Replicon chromosome
Accession NZ_CP093935
Organism Staphylococcus aureus strain WA121-2021_16354

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag MQP46_RS12770 Protein ID WP_000482652.1
Coordinates 2526586..2526693 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2526509..2526569 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP46_RS12755 2521964..2522095 - 132 WP_223197975.1 hypothetical protein -
MQP46_RS12760 2522362..2524095 - 1734 WP_000486487.1 ABC transporter ATP-binding protein -
MQP46_RS12765 2524120..2525883 - 1764 WP_001064825.1 ABC transporter ATP-binding protein -
- 2526509..2526569 + 61 - - Antitoxin
MQP46_RS12770 2526586..2526693 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
MQP46_RS12775 2526827..2527213 - 387 WP_000779360.1 flippase GtxA -
MQP46_RS12780 2527481..2528623 + 1143 WP_001176863.1 glycerate kinase -
MQP46_RS12785 2528683..2529342 + 660 WP_000831298.1 membrane protein -
MQP46_RS12790 2529524..2530735 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
MQP46_RS12795 2530858..2531331 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T239119 WP_000482652.1 NZ_CP093935:c2526693-2526586 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T239119 NZ_LR890606:1855246-1855497 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 61 bp

>AT239119 NZ_CP093935:2526509-2526569 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References