Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2501014..2501531 Replicon chromosome
Accession NZ_CP093935
Organism Staphylococcus aureus strain WA121-2021_16354

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MQP46_RS12635 Protein ID WP_000113265.1
Coordinates 2501014..2501280 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MQP46_RS12640 Protein ID WP_000584499.1
Coordinates 2501280..2501531 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP46_RS12605 (2496442) 2496442..2496978 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MQP46_RS12610 (2497212) 2497212..2498036 - 825 WP_000572038.1 formate/nitrite transporter family protein -
MQP46_RS12615 (2498253) 2498253..2498435 - 183 WP_000230292.1 hypothetical protein -
MQP46_RS12620 (2498519) 2498519..2498986 - 468 WP_000153347.1 SRPBCC domain-containing protein -
MQP46_RS12625 (2499172) 2499172..2500719 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MQP46_RS12630 (2500908) 2500908..2500979 - 72 Protein_2444 hypothetical protein -
MQP46_RS12635 (2501014) 2501014..2501280 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MQP46_RS12640 (2501280) 2501280..2501531 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MQP46_RS12645 (2501696) 2501696..2501776 - 81 WP_223197974.1 hypothetical protein -
MQP46_RS12650 (2501804) 2501804..2502403 - 600 WP_000162810.1 DsbA family protein -
MQP46_RS12655 (2502422) 2502422..2502784 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MQP46_RS12660 (2503039) 2503039..2504289 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MQP46_RS12665 (2504386) 2504386..2505117 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MQP46_RS12670 (2505114) 2505114..2505833 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T239118 WP_000113265.1 NZ_CP093935:c2501280-2501014 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T239118 NZ_LR890606:1062841-1063176 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT239118 WP_000584499.1 NZ_CP093935:c2501531-2501280 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT239118 NZ_LR890606:1062593-1062841 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References