Detailed information of TA system TA239111

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2070187..2070494
• Replicon: chromosome
• Accession: NZ_CP093935
• Organism: Staphylococcus aureus strain WA121-2021_16354

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MQP46_RS10340
• Protein ID: WP_011447039.1
• Coordinates: 2070318..2070494 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2070187..2070326 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQP46_RS10300 (2065525)	2065525..2065785	+	261	WP_001791826.1	hypothetical protein	-
MQP46_RS10305 (2065838)	2065838..2066188	-	351	WP_103150232.1	complement inhibitor SCIN-A	-
MQP46_RS10310 (2066873)	2066873..2067322	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
MQP46_RS10315 (2067417)	2067417..2067752	-	336	Protein_1995	SH3 domain-containing protein	-
MQP46_RS10320 (2068402)	2068402..2068893	-	492	WP_000920037.1	staphylokinase	-
MQP46_RS10325 (2069085)	2069085..2069840	-	756	WP_000861038.1	CHAP domain-containing protein	-
MQP46_RS10330 (2069852)	2069852..2070106	-	255	WP_000611512.1	phage holin	-
MQP46_RS10335 (2070158)	2070158..2070265	+	108	WP_001791821.1	hypothetical protein	-
- (2070187)	2070187..2070326	+	140	NuclAT_0	-	Antitoxin
- (2070187)	2070187..2070326	+	140	NuclAT_0	-	Antitoxin
- (2070187)	2070187..2070326	+	140	NuclAT_0	-	Antitoxin
- (2070187)	2070187..2070326	+	140	NuclAT_0	-	Antitoxin
MQP46_RS10340 (2070318)	2070318..2070494	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
MQP46_RS10345 (2070644)	2070644..2070940	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
MQP46_RS10350 (2070998)	2070998..2071285	-	288	WP_001040261.1	hypothetical protein	-
MQP46_RS10355 (2071332)	2071332..2071484	-	153	WP_001153681.1	hypothetical protein	-
MQP46_RS10360 (2071474)	2071474..2075259	-	3786	WP_103150169.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2065838..2117315	51477

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T239111 WP_011447039.1 NZ_CP093935:c2070494-2070318 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T239111 NZ_LR890605:c11424-11143 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCTGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGTCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT239111 NZ_CP093935:2070187-2070326 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin