Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1578839..1579418 | Replicon | chromosome |
| Accession | NZ_CP093935 | ||
| Organism | Staphylococcus aureus strain WA121-2021_16354 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | MQP46_RS07685 | Protein ID | WP_001025401.1 |
| Coordinates | 1579173..1579418 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1578839..1579204 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQP46_RS07625 (1574059) | 1574059..1574829 | - | 771 | WP_031873775.1 | conserved phage C-terminal domain-containing protein | - |
| MQP46_RS07630 (1574892) | 1574892..1575302 | + | 411 | WP_000429731.1 | hypothetical protein | - |
| MQP46_RS07635 (1575488) | 1575488..1576156 | - | 669 | WP_103250368.1 | putative HNHc nuclease | - |
| MQP46_RS07640 (1576170) | 1576170..1576589 | - | 420 | WP_000934777.1 | single-stranded DNA-binding protein | - |
| MQP46_RS07645 (1576589) | 1576589..1577212 | - | 624 | WP_000139721.1 | DUF1071 domain-containing protein | - |
| MQP46_RS07650 (1577205) | 1577205..1577426 | - | 222 | WP_000815401.1 | DUF2483 family protein | - |
| MQP46_RS07655 (1577436) | 1577436..1577696 | - | 261 | WP_001556704.1 | DUF1108 family protein | - |
| MQP46_RS07660 (1577701) | 1577701..1578018 | - | 318 | WP_000829610.1 | hypothetical protein | - |
| MQP46_RS07665 (1578108) | 1578108..1578269 | - | 162 | WP_001285949.1 | DUF1270 domain-containing protein | - |
| MQP46_RS07670 (1578281) | 1578281..1578544 | - | 264 | WP_001596347.1 | helix-turn-helix domain-containing protein | - |
| MQP46_RS07675 (1578569) | 1578569..1578784 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| MQP46_RS07680 (1578839) | 1578839..1579204 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| MQP46_RS07685 (1579173) | 1579173..1579418 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| MQP46_RS07690 (1579447) | 1579447..1580223 | - | 777 | WP_072519170.1 | Rha family transcriptional regulator | - |
| MQP46_RS07695 (1580237) | 1580237..1580473 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| MQP46_RS07700 (1580625) | 1580625..1580939 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| MQP46_RS07705 (1580952) | 1580952..1581413 | + | 462 | WP_103187915.1 | toxin | - |
| MQP46_RS07710 (1581431) | 1581431..1581865 | + | 435 | WP_000755719.1 | hypothetical protein | - |
| MQP46_RS07715 (1581894) | 1581894..1582289 | + | 396 | WP_000449655.1 | hypothetical protein | - |
| MQP46_RS07720 (1582380) | 1582380..1582526 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| MQP46_RS07725 (1582523) | 1582523..1583137 | - | 615 | WP_000191459.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukF-PV / lukS-PV | 1535993..1602093 | 66100 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T239104 WP_001025401.1 NZ_CP093935:c1579418-1579173 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T239104 NZ_LR890603:4078397-4078738 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
Antitoxin
Download Length: 366 bp
>AT239104 NZ_CP093935:1578839-1579204 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
