Detailed information of TA system TA239100

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2523699..2523883
• Replicon: chromosome
• Accession: NZ_CP093933
• Organism: Staphylococcus aureus strain WA121-2021_15363

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MQP45_RS12775
• Protein ID: WP_000482652.1
• Coordinates: 2523776..2523883 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2523699..2523759 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQP45_RS12760	2519154..2519285	-	132	WP_223197975.1	hypothetical protein	-
MQP45_RS12765	2519552..2521285	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MQP45_RS12770	2521310..2523073	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2523699..2523759	+	61	-	-	Antitoxin
MQP45_RS12775	2523776..2523883	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MQP45_RS12780	2524017..2524403	-	387	WP_000779360.1	flippase GtxA	-
MQP45_RS12785	2524671..2525813	+	1143	WP_001176863.1	glycerate kinase	-
MQP45_RS12790	2525873..2526532	+	660	WP_000831298.1	membrane protein	-
MQP45_RS12795	2526714..2527925	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MQP45_RS12800	2528048..2528521	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T239100 WP_000482652.1 NZ_CP093933:c2523883-2523776 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T239100 NZ_LR890603:2686707-2686814 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT239100 NZ_CP093933:2523699-2523759 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin