239099

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2498204..2498721 Replicon chromosome
Accession NZ_CP093933
Organism Staphylococcus aureus strain WA121-2021_15363

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MQP45_RS12640 Protein ID WP_000113265.1
Coordinates 2498204..2498470 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MQP45_RS12645 Protein ID WP_000584499.1
Coordinates 2498470..2498721 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP45_RS12610 (2493632) 2493632..2494168 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MQP45_RS12615 (2494402) 2494402..2495226 - 825 WP_000572038.1 formate/nitrite transporter family protein -
MQP45_RS12620 (2495443) 2495443..2495625 - 183 WP_000230292.1 hypothetical protein -
MQP45_RS12625 (2495709) 2495709..2496176 - 468 WP_000153347.1 SRPBCC domain-containing protein -
MQP45_RS12630 (2496362) 2496362..2497909 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MQP45_RS12635 (2498098) 2498098..2498169 - 72 Protein_2447 hypothetical protein -
MQP45_RS12640 (2498204) 2498204..2498470 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MQP45_RS12645 (2498470) 2498470..2498721 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MQP45_RS12650 (2498886) 2498886..2498966 - 81 WP_223197974.1 hypothetical protein -
MQP45_RS12655 (2498994) 2498994..2499593 - 600 WP_000162810.1 DsbA family protein -
MQP45_RS12660 (2499612) 2499612..2499974 - 363 WP_168752955.1 DUF4467 domain-containing protein -
MQP45_RS12665 (2500229) 2500229..2501479 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MQP45_RS12670 (2501576) 2501576..2502307 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MQP45_RS12675 (2502304) 2502304..2503023 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T239099 WP_000113265.1 NZ_CP093933:c2498470-2498204 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T239099 NZ_LR890603:2686172-2686279 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT239099 WP_000584499.1 NZ_CP093933:c2498721-2498470 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT239099 NZ_LR890603:c2686125-2686059 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References