Detailed information of TA system TA239089

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1904472..1904652
• Replicon: chromosome
• Accession: NZ_CP093933
• Organism: Staphylococcus aureus strain WA121-2021_15363

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MQP45_RS09305
• Protein ID: WP_001801861.1
• Coordinates: 1904472..1904567 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1904595..1904652 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQP45_RS09275	1899635..1900285	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MQP45_RS09280	1900366..1901361	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MQP45_RS09285	1901436..1902062	+	627	WP_000669024.1	hypothetical protein	-
MQP45_RS09290	1902103..1902444	+	342	WP_000627540.1	DUF3969 family protein	-
MQP45_RS09295	1902545..1903117	+	573	WP_000414216.1	hypothetical protein	-
MQP45_RS09300	1903315..1904327	-	1013	Protein_1831	IS3 family transposase	-
MQP45_RS09305	1904472..1904567	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1904595..1904652	-	58	-	-	Antitoxin
MQP45_RS09310	1904690..1904791	+	102	WP_001792025.1	hypothetical protein	-
MQP45_RS09315	1904769..1904930	-	162	Protein_1834	transposase	-
MQP45_RS09320	1904915..1905325	-	411	WP_001808705.1	IS21 family transposase	-
MQP45_RS09325	1905867..1907096	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MQP45_RS09330	1907089..1908645	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MQP45_RS09335	1908809..1908943	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1880454..1931485	51031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T239089 WP_001801861.1 NZ_CP093933:1904472-1904567 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T239089 NZ_LR890603:836278-836685 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT239089 NZ_CP093933:c1904652-1904595 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin