Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1575068..1575647 | Replicon | chromosome |
| Accession | NZ_CP093933 | ||
| Organism | Staphylococcus aureus strain WA121-2021_15363 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | MQP45_RS07675 | Protein ID | WP_001025401.1 |
| Coordinates | 1575402..1575647 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1575068..1575433 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MQP45_RS07615 (1570288) | 1570288..1571058 | - | 771 | WP_031873775.1 | conserved phage C-terminal domain-containing protein | - |
| MQP45_RS07620 (1571121) | 1571121..1571531 | + | 411 | WP_000429731.1 | hypothetical protein | - |
| MQP45_RS07625 (1571717) | 1571717..1572385 | - | 669 | WP_103250368.1 | putative HNHc nuclease | - |
| MQP45_RS07630 (1572399) | 1572399..1572818 | - | 420 | WP_000934777.1 | single-stranded DNA-binding protein | - |
| MQP45_RS07635 (1572818) | 1572818..1573441 | - | 624 | WP_000139721.1 | DUF1071 domain-containing protein | - |
| MQP45_RS07640 (1573434) | 1573434..1573655 | - | 222 | WP_000815401.1 | DUF2483 family protein | - |
| MQP45_RS07645 (1573665) | 1573665..1573925 | - | 261 | WP_001556704.1 | DUF1108 family protein | - |
| MQP45_RS07650 (1573930) | 1573930..1574247 | - | 318 | WP_000829610.1 | hypothetical protein | - |
| MQP45_RS07655 (1574337) | 1574337..1574498 | - | 162 | WP_001285949.1 | DUF1270 domain-containing protein | - |
| MQP45_RS07660 (1574510) | 1574510..1574773 | - | 264 | WP_001596347.1 | helix-turn-helix domain-containing protein | - |
| MQP45_RS07665 (1574798) | 1574798..1575013 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| MQP45_RS07670 (1575068) | 1575068..1575433 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| MQP45_RS07675 (1575402) | 1575402..1575647 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| MQP45_RS07680 (1575676) | 1575676..1576452 | - | 777 | WP_072519170.1 | Rha family transcriptional regulator | - |
| MQP45_RS07685 (1576466) | 1576466..1576702 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| MQP45_RS07690 (1576854) | 1576854..1577168 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| MQP45_RS07695 (1577181) | 1577181..1577642 | + | 462 | WP_103187915.1 | toxin | - |
| MQP45_RS07700 (1577660) | 1577660..1578094 | + | 435 | WP_000755719.1 | hypothetical protein | - |
| MQP45_RS07705 (1578123) | 1578123..1578518 | + | 396 | WP_000449655.1 | hypothetical protein | - |
| MQP45_RS07710 (1578609) | 1578609..1578755 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| MQP45_RS07715 (1578752) | 1578752..1579366 | - | 615 | WP_000191459.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukF-PV / lukS-PV | 1535597..1598322 | 62725 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T239085 WP_001025401.1 NZ_CP093933:c1575647-1575402 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T239085 NZ_LR890601:70679-70966 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 366 bp
>AT239085 NZ_CP093933:1575068-1575433 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
