Detailed information of TA system TA239081

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2523210..2523394
• Replicon: chromosome
• Accession: NZ_CP093930
• Organism: Staphylococcus aureus strain WA121-2010_15611

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MPM52_RS12765
• Protein ID: WP_000482652.1
• Coordinates: 2523287..2523394 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2523210..2523270 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPM52_RS12750	2518665..2518796	-	132	WP_223197975.1	hypothetical protein	-
MPM52_RS12755	2519063..2520796	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MPM52_RS12760	2520821..2522584	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2523210..2523270	+	61	-	-	Antitoxin
MPM52_RS12765	2523287..2523394	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MPM52_RS12770	2523528..2523914	-	387	WP_000779360.1	flippase GtxA	-
MPM52_RS12775	2524182..2525324	+	1143	WP_001176863.1	glycerate kinase	-
MPM52_RS12780	2525384..2526043	+	660	WP_000831298.1	membrane protein	-
MPM52_RS12785	2526225..2527436	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MPM52_RS12790	2527559..2528032	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T239081 WP_000482652.1 NZ_CP093930:c2523394-2523287 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T239081 NZ_LR890600:c5197560-5197177 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT239081 NZ_CP093930:2523210-2523270 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin