Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2497715..2498232 Replicon chromosome
Accession NZ_CP093930
Organism Staphylococcus aureus strain WA121-2010_15611

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MPM52_RS12630 Protein ID WP_000113265.1
Coordinates 2497715..2497981 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MPM52_RS12635 Protein ID WP_000584499.1
Coordinates 2497981..2498232 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPM52_RS12600 (2493143) 2493143..2493679 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
MPM52_RS12605 (2493913) 2493913..2494737 - 825 WP_000572038.1 formate/nitrite transporter family protein -
MPM52_RS12610 (2494954) 2494954..2495136 - 183 WP_000230292.1 hypothetical protein -
MPM52_RS12615 (2495220) 2495220..2495687 - 468 WP_000153347.1 SRPBCC domain-containing protein -
MPM52_RS12620 (2495873) 2495873..2497420 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MPM52_RS12625 (2497609) 2497609..2497680 - 72 Protein_2443 hypothetical protein -
MPM52_RS12630 (2497715) 2497715..2497981 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MPM52_RS12635 (2497981) 2497981..2498232 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MPM52_RS12640 (2498397) 2498397..2498477 - 81 WP_223197974.1 hypothetical protein -
MPM52_RS12645 (2498505) 2498505..2499104 - 600 WP_000162810.1 DsbA family protein -
MPM52_RS12650 (2499123) 2499123..2499485 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MPM52_RS12655 (2499740) 2499740..2500990 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MPM52_RS12660 (2501087) 2501087..2501818 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MPM52_RS12665 (2501815) 2501815..2502534 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T239080 WP_000113265.1 NZ_CP093930:c2497981-2497715 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T239080 NZ_CP093930:c2497981-2497715 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT239080 WP_000584499.1 NZ_CP093930:c2498232-2497981 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT239080 NZ_CP093930:c2498232-2497981 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References