Detailed information of TA system TA239073

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2066888..2067195
• Replicon: chromosome
• Accession: NZ_CP093930
• Organism: Staphylococcus aureus strain WA121-2010_15611

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MPM52_RS10330
• Protein ID: WP_011447039.1
• Coordinates: 2067019..2067195 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2066888..2067027 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPM52_RS10290 (2062226)	2062226..2062486	+	261	WP_001791826.1	hypothetical protein	-
MPM52_RS10295 (2062539)	2062539..2062889	-	351	WP_103150232.1	complement inhibitor SCIN-A	-
MPM52_RS10300 (2063574)	2063574..2064023	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
MPM52_RS10305 (2064118)	2064118..2064453	-	336	Protein_1993	SH3 domain-containing protein	-
MPM52_RS10310 (2065103)	2065103..2065594	-	492	WP_000920037.1	staphylokinase	-
MPM52_RS10315 (2065786)	2065786..2066541	-	756	WP_000861038.1	CHAP domain-containing protein	-
MPM52_RS10320 (2066553)	2066553..2066807	-	255	WP_000611512.1	phage holin	-
MPM52_RS10325 (2066859)	2066859..2066966	+	108	WP_001791821.1	hypothetical protein	-
- (2066888)	2066888..2067027	+	140	NuclAT_0	-	Antitoxin
- (2066888)	2066888..2067027	+	140	NuclAT_0	-	Antitoxin
- (2066888)	2066888..2067027	+	140	NuclAT_0	-	Antitoxin
- (2066888)	2066888..2067027	+	140	NuclAT_0	-	Antitoxin
MPM52_RS10330 (2067019)	2067019..2067195	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
MPM52_RS10335 (2067345)	2067345..2067641	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
MPM52_RS10340 (2067699)	2067699..2067986	-	288	WP_001040261.1	hypothetical protein	-
MPM52_RS10345 (2068033)	2068033..2068185	-	153	WP_001153681.1	hypothetical protein	-
MPM52_RS10350 (2068175)	2068175..2071960	-	3786	WP_103150169.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2062539..2114016	51477

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T239073 WP_011447039.1 NZ_CP093930:c2067195-2067019 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T239073 NZ_LR890600:736826-737308 [Klebsiella pneumoniae]
ATGGAAATAAATGTCACTGCGCCTGCTTTACTGACAGAGGAGCATGTTCTTCATTCGTTCGATTGCGGGAATGCGGTACT
TGATGACTGGCTTCGCCGGCGTGCGTTGAAGAATCAGCATCTTAATGCTTCCCGGACATTCGTCATCTGTCCTGAAGGTA
CTGCGTGTGTAGTGGGTTATTATTCCCTTGCGACGGGCTCAGTTAGTCATGTCGACTTGAGTCGTAGTCTGCGACAGAAT
ATGCCCGATCCCGTACCGGTTGTTTTGCTGGGCCGCCTTGCAGTCGATGTATCCACTCAGGGCAATAACTTCGGGAAATG
GTTGCTGAATGATGCTGTGATGCGCGTATCGAATCTGGCGGATCAGGTCGGCATCAAGGCTATCATGGTGCATGCAATTG
ATGAGCGGGCTAAAGCGTTCTATGAATACTTTGGTTTTGTGCAGTCACCGGTTGCGGCTAACACGCTTTTCTACAAAATA
TAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT239073 NZ_CP093930:2066888-2067027 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin