Detailed information of TA system TA239070

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1904973..1905153
• Replicon: chromosome
• Accession: NZ_CP093930
• Organism: Staphylococcus aureus strain WA121-2010_15611

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MPM52_RS09305
• Protein ID: WP_001801861.1
• Coordinates: 1904973..1905068 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1905096..1905153 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPM52_RS09275	1900136..1900786	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
MPM52_RS09280	1900867..1901862	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
MPM52_RS09285	1901937..1902563	+	627	WP_000669024.1	hypothetical protein	-
MPM52_RS09290	1902604..1902945	+	342	WP_000627540.1	DUF3969 family protein	-
MPM52_RS09295	1903046..1903618	+	573	WP_000414216.1	hypothetical protein	-
MPM52_RS09300	1903816..1904828	-	1013	Protein_1830	IS3 family transposase	-
MPM52_RS09305	1904973..1905068	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1905096..1905153	-	58	-	-	Antitoxin
MPM52_RS09310	1905191..1905292	+	102	WP_001792025.1	hypothetical protein	-
MPM52_RS09315	1905270..1905431	-	162	Protein_1833	transposase	-
MPM52_RS09320	1905416..1905826	-	411	WP_001808705.1	IS21 family transposase	-
MPM52_RS09325	1906368..1907597	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
MPM52_RS09330	1907590..1909146	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MPM52_RS09335	1909310..1909444	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1880955..1940923	59968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T239070 WP_001801861.1 NZ_CP093930:1904973-1905068 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T239070 NZ_LR890600:337711-338079 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT239070 NZ_CP093930:c1905153-1905096 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin