Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1575569..1576148 | Replicon | chromosome |
| Accession | NZ_CP093930 | ||
| Organism | Staphylococcus aureus strain WA121-2010_15611 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | MPM52_RS07675 | Protein ID | WP_001025401.1 |
| Coordinates | 1575903..1576148 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1575569..1575934 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MPM52_RS07615 (1570789) | 1570789..1571559 | - | 771 | WP_031873775.1 | conserved phage C-terminal domain-containing protein | - |
| MPM52_RS07620 (1571622) | 1571622..1572032 | + | 411 | WP_000429731.1 | hypothetical protein | - |
| MPM52_RS07625 (1572218) | 1572218..1572886 | - | 669 | WP_103250368.1 | putative HNHc nuclease | - |
| MPM52_RS07630 (1572900) | 1572900..1573319 | - | 420 | WP_000934777.1 | single-stranded DNA-binding protein | - |
| MPM52_RS07635 (1573319) | 1573319..1573942 | - | 624 | WP_000139721.1 | DUF1071 domain-containing protein | - |
| MPM52_RS07640 (1573935) | 1573935..1574156 | - | 222 | WP_000815401.1 | DUF2483 family protein | - |
| MPM52_RS07645 (1574166) | 1574166..1574426 | - | 261 | WP_001556704.1 | DUF1108 family protein | - |
| MPM52_RS07650 (1574431) | 1574431..1574748 | - | 318 | WP_000829610.1 | hypothetical protein | - |
| MPM52_RS07655 (1574838) | 1574838..1574999 | - | 162 | WP_001285949.1 | DUF1270 domain-containing protein | - |
| MPM52_RS07660 (1575011) | 1575011..1575274 | - | 264 | WP_001596347.1 | helix-turn-helix domain-containing protein | - |
| MPM52_RS07665 (1575299) | 1575299..1575514 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| MPM52_RS07670 (1575569) | 1575569..1575934 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| MPM52_RS07675 (1575903) | 1575903..1576148 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| MPM52_RS07680 (1576177) | 1576177..1576953 | - | 777 | WP_072519170.1 | Rha family transcriptional regulator | - |
| MPM52_RS07685 (1576967) | 1576967..1577203 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| MPM52_RS07690 (1577355) | 1577355..1577669 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | - |
| MPM52_RS07695 (1577682) | 1577682..1578143 | + | 462 | WP_103187915.1 | toxin | - |
| MPM52_RS07700 (1578161) | 1578161..1578595 | + | 435 | WP_000755719.1 | hypothetical protein | - |
| MPM52_RS07705 (1578624) | 1578624..1579019 | + | 396 | WP_000449655.1 | hypothetical protein | - |
| MPM52_RS07710 (1579110) | 1579110..1579256 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| MPM52_RS07715 (1579253) | 1579253..1579867 | - | 615 | WP_000191459.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukF-PV / lukS-PV | 1536099..1598823 | 62724 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T239066 WP_001025401.1 NZ_CP093930:c1576148-1575903 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T239066 NZ_LR890595:c4588883-4588350 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGGCAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAAAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGGCAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAAAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 366 bp
>AT239066 NZ_CP093930:1575569-1575934 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
