Detailed information of TA system TA239059

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 37136..37405
• Replicon: plasmid pGA_Eco2
• Accession: NZ_CP093922
• Organism: Escherichia coli strain ST167

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MOO49_RS24730
• Protein ID: WP_001372321.1
• Coordinates: 37280..37405 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	37136..37201 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOO49_RS24685 (32158)	32158..32430	+	273	WP_072118979.1	hypothetical protein	-
MOO49_RS24690 (32671)	32671..32877	+	207	WP_000275853.1	hypothetical protein	-
MOO49_RS24695 (32903)	32903..33442	+	540	WP_242806077.1	single-stranded DNA-binding protein	-
MOO49_RS24700 (33505)	33505..33738	+	234	WP_000005990.1	DUF905 family protein	-
MOO49_RS24705 (33804)	33804..35762	+	1959	WP_242806079.1	ParB/RepB/Spo0J family partition protein	-
MOO49_RS24710 (35817)	35817..36251	+	435	WP_242806081.1	conjugation system SOS inhibitor PsiB	-
MOO49_RS24715 (36248)	36248..37010	+	763	Protein_47	plasmid SOS inhibition protein A	-
MOO49_RS24720 (36979)	36979..37167	-	189	WP_001299721.1	hypothetical protein	-
- (37136)	37136..37201	+	66	NuclAT_1	-	-
- (37136)	37136..37201	-	66	NuclAT_0	-	Antitoxin
- (37136)	37136..37201	-	66	NuclAT_0	-	Antitoxin
- (36979)	36979..37203	+	225	NuclAT_0	-	-
- (36979)	36979..37203	+	225	NuclAT_0	-	-
- (36979)	36979..37203	+	225	NuclAT_0	-	-
- (36979)	36979..37203	+	225	NuclAT_0	-	-
- (36979)	36979..37203	-	225	NuclAT_0	-	-
MOO49_RS24725 (37189)	37189..37338	+	150	Protein_49	plasmid maintenance protein Mok	-
MOO49_RS24730 (37280)	37280..37405	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
MOO49_RS24735 (37853)	37853..38026	-	174	Protein_51	hypothetical protein	-
MOO49_RS24740 (38096)	38096..38302	+	207	WP_052908079.1	hypothetical protein	-
MOO49_RS24745 (38327)	38327..38614	+	288	WP_000107548.1	hypothetical protein	-
MOO49_RS24750 (38733)	38733..39554	+	822	WP_157906015.1	DUF932 domain-containing protein	-
MOO49_RS24755 (39851)	39851..40453	-	603	WP_077815103.1	transglycosylase SLT domain-containing protein	-
MOO49_RS24760 (40772)	40772..41155	+	384	WP_001151524.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MOO49_RS24765 (41342)	41342..42031	+	690	WP_097730119.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T239059 WP_001372321.1 NZ_CP093922:37280-37405 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T239059 NZ_LR890584:c97471-96986 [Klebsiella pneumoniae]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAAGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT239059 NZ_CP093922:c37201-37136 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin