Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2541581..2542219 Replicon chromosome
Accession NZ_CP093919
Organism Escherichia coli strain ST167

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag MOO49_RS12175 Protein ID WP_001447010.1
Coordinates 2542043..2542219 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MOO49_RS12170 Protein ID WP_001270286.1
Coordinates 2541581..2541997 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO49_RS12150 (2536733) 2536733..2537674 - 942 WP_001251304.1 ABC transporter permease -
MOO49_RS12155 (2537675) 2537675..2538688 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
MOO49_RS12160 (2538706) 2538706..2539851 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
MOO49_RS12165 (2540096) 2540096..2541502 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
MOO49_RS12170 (2541581) 2541581..2541997 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
MOO49_RS12175 (2542043) 2542043..2542219 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
MOO49_RS12180 (2542441) 2542441..2542671 + 231 WP_000494244.1 YncJ family protein -
MOO49_RS12185 (2542763) 2542763..2544724 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
MOO49_RS12190 (2544797) 2544797..2545333 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
MOO49_RS12195 (2545425) 2545425..2546600 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2546640..2547788 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T239044 WP_001447010.1 NZ_CP093919:c2542219-2542043 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T239044 NZ_LR890572:53790-54272 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT239044 WP_001270286.1 NZ_CP093919:c2541997-2541581 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT239044 NZ_LR890572:53536-53802 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References