239029

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721536..722229 Replicon chromosome
Accession NZ_CP093919
Organism Escherichia coli strain ST167

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MOO49_RS03525 Protein ID WP_000415584.1
Coordinates 721536..721832 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MOO49_RS03530 Protein ID WP_000650107.1
Coordinates 721834..722229 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOO49_RS03490 (716624) 716624..716938 - 315 WP_000958598.1 putative quinol monooxygenase -
MOO49_RS03495 (716969) 716969..717550 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MOO49_RS03500 (717869) 717869..718201 + 333 WP_000917685.1 DUF2645 family protein -
MOO49_RS03505 (718247) 718247..719596 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MOO49_RS03510 (719593) 719593..720252 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MOO49_RS03515 (720404) 720404..720796 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MOO49_RS03520 (720849) 720849..721331 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MOO49_RS03525 (721536) 721536..721832 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MOO49_RS03530 (721834) 721834..722229 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MOO49_RS03535 (722362) 722362..723969 + 1608 WP_087523553.1 ABC transporter substrate-binding protein -
MOO49_RS03540 (724107) 724107..726365 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T239029 WP_000415584.1 NZ_CP093919:721536-721832 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T239029 NZ_LR890569:c4677612-4677328 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT239029 WP_000650107.1 NZ_CP093919:721834-722229 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT239029 NZ_LR890569:c4677844-4677602 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References